ArticleBMC infectious diseases2020
Enterobacter cloacae colonisation and infection in a neonatal intensive care unit: retrospective investigation of preventive measures implemented after a multiclonal outbreak.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pathogenic characterization and drug resistance of neonatal sepsis in China: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Pooled it
- Precise species identification and whole-genome sequencing analysis ofMicrobiology spectrum · 2026Article
- Molecular Characterization of Gram-Negative Bacilli Isolated from a Neonatal Intensive Care Unit and Phenotypic and Molecular Detection of ESBL and Carbapenemase.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Alterations of the paired maternal fecal microbiota and neonatal meconium microbiota in newborns from pregnant women with hypertensive disorders.Frontiers in microbiology · 2025Article
- Antibiotic-resistant bacteria contaminating leafy vegetables in Saudi Arabia's eastern region.BMC microbiology · 2024Article
- Linking preterm infant gut microbiota to nasograstric enteral feeding tubes: exploring potential interactions and microbial strain transmission.Frontiers in pediatrics · 2024Article
- Distribution and diversity of type VI secretion system clusters inMicrobial genomics · 2023Article
- Article
- Molecular surveillance reveals widespread colonisation by carbapenemase and extended spectrum beta-lactamase producing organisms in neonatal units in Kenya and Nigeria.Antimicrobial resistance and infection control · 2023Article
- Prevalence, antibiotic resistance patterns, and biofilm formation ability ofVeterinary world · 2023Article
- Unraveling the Virulence Factors and Secreted Proteins of an Environmental Isolate Enterobacter sp. S-16.Current microbiology · 2023Article
- The Epidemiological Pattern, Resistance Characteristics and Clinical Outcome ofHealthcare (Basel, Switzerland) · 2023Article
- Contaminated Incubators: Source of a Multispecies Enterobacter Outbreak of Neonatal Sepsis.Microbiology spectrum · 2022Article
- Two Newly IsolatedViruses · 2022Article
- Multidrug-Resistant Gram-Negative Bacteria and Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae from the Poultry Farm Environment.Microbiology spectrum · 2022Article
- Surveillance of Enterobacter cloacae complex colonization and comparative analysis of different typing methods on a neonatal intensive care unit in Germany.Antimicrobial resistance and infection control · 2022Article
- Dominant bacteria and influencing factors of early intestinal colonization in very low birth weight infants: A prospective cohort study.Journal of clinical laboratory analysis · 2022Article
- Functional Annotation of Hypothetical Proteins From theBioinformatics and biology insights · 2022Article
- Emergence of Neonatal Sepsis Caused by MCR-9- and NDM-1-Co-ProducingFrontiers in cellular and infection microbiology · 2022Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterobacter cloacae species is responsible for nosocomial outbreaks in vulnerable patients in neonatal intensive care units (NICU). The environment can constitute the reservoir and source of infection in NICUs. Herein we report the impact of preventive measures implemented after an Enterobacter cloacae outbreak inside a NICU.
methodsThis retrospective study was conducted in one level 3 NICU in Lyon, France, over a 6 year-period (2012-2018). After an outbreak of Enterobacter cloacae infections in hospitalized neonates in 2013, several measures were implemented including intensive biocleaning and education of medical staff. Clinical and microbiological characteristics of infected patients and evolution of colonization/infection with Enterobacter spp. in this NICU were retrieved. Moreover, whole genome sequencing was performed on 6 outbreak strains.
resultsEnterobacter spp. was isolated in 469 patients and 30 patients developed an infection including 2 meningitis and 12 fatal cases. Preventive measures and education of medical staff were not associated with a significant decrease in patient colonisation but led to a persistent decreased use of cephalosporin in the NICU. Infection strains were genetically diverse, supporting the hypothesis of multiple hygiene defects rather than the diffusion of a single clone.
conclusionsGrouped cases of infections inside one setting are not necessarily related to a single-clone outbreak and could reveal other environmental and organisational problematics. The fight against implementation and transmission of Enterobacter spp. in NICUs remains a major challenge.
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