Evidence map›Paper›PMID 32942669›Full record

ArticleInternational journal of molecular sciences2020

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia.

Mikhail Korokin, Vladimir Gureev, Oleg Gudyrev, Ivan Golubev, Liliya Korokina, Anna Peresypkina, Tatiana Pokrovskaia, Galina Lazareva, Vladislav Soldatov, Mariya Zatolokina and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Peptides for Health Benefits 2020.International journal of molecular sciences · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Mikhail KorokinDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Vladimir GureevDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0003-1433-1225
Oleg GudyrevDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Ivan GolubevDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Liliya KorokinaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Anna PeresypkinaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Tatiana PokrovskaiaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Galina LazarevaDepartment of Obstetrics and Gynecology FPE, Kursk State Medical University, 305000 Kursk, Russia.
Vladislav SoldatovDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Mariya ZatolokinaDepartment of Histology, Embryology, Cytology, Kursk State Medical University, 305000 Kursk, Russia.
Anna PobedaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Elena AvdeevaDepartment of Normal Physiology, Kursk State Medical University, 305000 Kursk, Russia.
Evgeniya BeskhmelnitsynaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.ORCID 0000-0001-6009-5740
Tatyana DenisyukDepartment of Pharmacology, Kursk State Medical University, 305000 Kursk, Russia.
Natalia AvdeevaDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Olga BushuevaResearch Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305000 Kursk, Russia.
Mikhail PokrovskiiDepartment of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.
Belgorod National Research University · RUKursk State Medical University · RU

Funding

Grant from the President of the Russian Federation for young scientists MD-757.2020.7
6 · The paper itself

Abstract

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 µg/kg and 250 µg/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 µg/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (

Indexed as

Animalsbcl-2-Associated X ProteinBlood PressureDisease Models, AnimalEndothelial CellsEndothelium, VascularErythropoietinFemaleMicrocirculationNG-Nitroarginine Methyl EsterOligopeptidesPlacentaPre-EclampsiaPregnancyProto-Oncogene Proteins c-bcl-2Ratsbcl-2-Associated X ProteincibinetideErythropoietinNG-Nitroarginine Methyl EsterOligopeptidesProto-Oncogene Proteins c-bcl-2endothelial dysfunctionerythropoietin-derived peptidepHBSPplacentapreeclampsiaWistar rats

Identifiers

PMID32942669
PMCPMC7554893
OpenAlexW3084758133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.