Evidence map›Paper›PMID 32942585›Full record

SynthesisInternational journal of molecular sciences2020

The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review.

Mojgan Gharipour, Majid Barekatain, Johoon Sung, Naghmeh Emami, Ladan Sadeghian, Minoo Dianatkhah, Nizal Sarrafzadegan, Shayesteh Jahanfar

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Genetics of Common Obesity in Children and Adolescents.Annals of the New York Academy of Sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Obesity and Depression: Common Link and Possible Targets.CNS & neurological disorders drug targets · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Mojgan GharipourIsfahan Cardiovascular Research Center, Genetics and Epigenetics Department, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.
Majid BarekatainDepartment of Psychiatry, School of Medicine and Behavioral Science Research Center, Isfahan University of Medical Science, Isfahan 8174673461, Iran.
Johoon SungDepartment Public Health Science, Genome & Health Big Data, Seoul National University, Seoul 05649, Korea.ORCID 0000-0001-9948-0160
Naghmeh EmamiResearch Department, Interventional Cardiology Research Center, Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.
Ladan SadeghianResearch Department, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.ORCID 0000-0002-3534-9304
Minoo DianatkhahResearch Department, Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.
Nizal SarrafzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.
Shayesteh JahanfarMPH Program, School of Public Health, Central Michigan University, Mount Pleasant, MI 48859, USA.ORCID 0000-0001-6149-1067
Isfahan University of Medical Sciences · IRCentral Michigan University · USSeoul National University · KRUniversity of Isfahan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Obesity and mood disorders are considered as the most prevalent morbidities in many countries. We suppose that epigenetic mechanisms may induce higher rates of obesity in subjects who suffer from mood disorders. In this systematic review, we focused on the potential roles of DNA methylation on mood disorders and obesity development. (2) Methods: This systematic review was conducted in accordance with the PRISMA statement and registered in Prospero. A systematic search was conducted in MEDLINE, Scopus, Web of Science, Cochrane Central database, EMBASE, and CINHAL. We also conducted a Grey literature search, such as Google Scholar. (3) Results: After deduplication, we identified 198 potentially related citations. Finally, ten unique studies met our inclusion criteria. We have found three overlap genes that show significant DNA methylation changes, both in obesity and depression. Pathway analysis interaction for

Indexed as

AnimalsEpigenesis, GeneticEpigenomicsHumansInflammationMood DisordersObesitySignal Transductiondepressionepigeneticsmood disordersobesity

Identifiers

PMID32942585
PMCPMC7555814
OpenAlexW3084935900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.