Evidence map›Paper›PMID 32942546›Full record

ArticleInternational journal of molecular sciences2020

Ligation-Mediated Polymerase Chain Reaction Detection of 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 5-Hydroxycytosine at the Codon 176 of the p53 Gene of Hepatitis C-Associated Hepatocellular Carcinoma Patients.

Andrea Galli, Armelle Munnia, Filippo Cellai, Mirko Tarocchi, Elisabetta Ceni, Frederik Jan van Schooten, Roger Godschalk, Roger W Giese, Marco Peluso

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea GalliDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy.
Armelle MunniaResearch Branch, Regional Cancer Prevention Laboratory, ISPRO-Study, Prevention and Oncology Network Institute, 50139 Florence, Italy.
Filippo CellaiResearch Branch, Regional Cancer Prevention Laboratory, ISPRO-Study, Prevention and Oncology Network Institute, 50139 Florence, Italy.
Mirko TarocchiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy.
Elisabetta CeniDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy.
Frederik Jan van SchootenDepartment of Pharmacology & Toxicology, Maastricht University, 6229 ER Maastricht, The Netherlands.
Roger GodschalkDepartment of Pharmacology & Toxicology, Maastricht University, 6229 ER Maastricht, The Netherlands.
Roger W GieseBouve College of Health Sciences, Barnett Institute, Northeastern University, Boston, MA 02115, USA.
Marco PelusoResearch Branch, Regional Cancer Prevention Laboratory, ISPRO-Study, Prevention and Oncology Network Institute, 50139 Florence, Italy.ORCID 0000-0001-7646-7967

Funding

Istituto Toscano Tumori na
6 · The paper itself

Abstract

Molecular mechanisms underlying Hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) pathogenesis are still unclear. Therefore, we analyzed the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and other oxidative lesions at codon 176 of the p53 gene, as well as the generation of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M

Indexed as

8-Hydroxy-2'-DeoxyguanosineCarcinoma, HepatocellularCell Line, TumorCodonCytosineDNA AdductsGenes, p53HepacivirusHepatitis CHep G2 CellsHumansLipid PeroxidationLiver NeoplasmsPolymerase Chain ReactionReactive Oxygen Species5-hydroxycytosine8-Hydroxy-2'-DeoxyguanosineCodonCytosineDNA AdductsReactive Oxygen Species8-oxodGHCCHCVM1dGp53

Identifiers

PMID32942546
PMCPMC7555735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.