Evidence map›Paper›PMID 32942527›Full record

ReviewInternational journal of molecular sciences2020

Protein Biomarkers for the Diagnosis of Alzheimer's Disease at Different Stages of Neurodegeneration.

Mar Pérez, Félix Hernández, Jesús Avila

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mar PérezDepartamento de Anatomía Histología y Neurociencia, Facultad de Medicina UAM, 28029 Madrid, Spain.
Félix HernándezCentro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain.
Jesús AvilaCentro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain.ORCID 0000-0002-6288-0571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mainly obtained from familial Alzheimer's disease patients' data, we know that some features of the neurodegenerative start several years before the appearance of clinical symptoms. In this brief review, we comment on some molecular and cellular markers appearing at different stages of the disease, before or once the clinical symptoms are evident. These markers are present in biological fluids or could be identified by image techniques. The combined use of molecular and cellular markers will be of interest to determine the development of the different phases of the disease.

Indexed as

Alzheimer DiseaseAnimalsBiomarkersHumansNeurodegenerative DiseasesProteinsBiomarkersProteinsamyloidCSFPETtau

Identifiers

PMID32942527
PMCPMC7554800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.