Evidence map›Paper›PMID 32942317›Full record

ArticleEndoscopy2021

Gastric adenomas and their management in familial adenomatous polyposis.

Isabel Martin, Victorine H Roos, Chukwuemeka Anele, Sarah-Jane Walton, Victoria Cuthill, Noriko Suzuki, Barbara A Bastiaansen, Susan K Clark, Alexander von Roon, Evelien Dekker and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  17. Cancer Progress and Priorities: Gastric Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Isabel MartinThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
Victorine H RoosDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Netherlands.
Chukwuemeka AneleThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
Sarah-Jane WaltonDepartment of Surgery, Basildon and Thurrock University Hospital, Basildon, United Kingdom.
Victoria CuthillThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
Noriko SuzukiThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
Barbara A BastiaansenDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Netherlands.
Susan K ClarkThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
Alexander von RoonDepartment of Surgery, University College Hospital, London, United Kingdom.
Evelien DekkerDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Netherlands.
Andrew LatchfordThe Polyposis Registry, St. Mark's Hospital, London, United Kingdom.
St Mark's Hospital · GBUniversity of Amsterdam · NLImperial College London · GBBasildon and Thurrock University Hospitals NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric adenomas. There is limited understanding of their clinical course and no consensus on management. We reviewed the management of gastric adenomas in patients with FAP from two centers.

methodsPatients with FAP and histologically confirmed gastric adenomas were identified between 1997 and 2018. Patient demographics, adenoma characteristics, and management/surveillance outcomes were collected.

resultsOf 726 patients with FAP, 104 (14 %; 49 female) were diagnosed with gastric adenomas at a median age of 47 years (range 19 - 80). The median size of gastric adenomas was 6 mm (range 1.5 - 50); 64 (62 %) patients had adenomas located distally to the incisura. Five patients (5 %) had gastric adenomas demonstrating high-grade dysplasia (HGD) on initial diagnosis, distributed equally within the stomach. The risk of HGD was associated with adenoma size (

conclusionsWe observed gastric adenomas in 14 % of patients with FAP. Of these, 5 % contained HGD; risk of HGD correlated with adenoma size. Endoscopic resection was feasible, with few complications and low recurrence rates, but did not completely eliminate the cancer risk.

Indexed as

AdenomaAdenomatous Polyposis ColiStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansMiddle AgedNeoplasm Recurrence, LocalYoung Adult

Identifiers

PMID32942317
PMCPMC8315898
OpenAlexW3087569608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.