ArticleNeuroImage. Clinical2020
Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The Amyloid-β Pathway in Alzheimer's Disease.Molecular psychiatry · 2021Pooled it
- A NOVEL BAYESIAN FRAMEWORK UNCOVERING BRAIN CONNECTIVITY-TO-SHAPE RELATIONSHIP IN PRECLINICAL ALZHEIMER'S DISEASE.The annals of applied statistics · 2026Article
- Assessing the link between cerebellar volume and cognitive function in Alzheimer's disease: a pilot study.Scientific reports · 2025Article
- Modeling functional connectivity with learning and memory in a mouse model of Alzheimer's disease.Frontiers in neuroimaging · 2025Article
- Cortical morphology changes in default mode network regions as predictors of cognitive decline in relation to amyloid and tau deposits.Brain communications · 2025Article
- Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias.Annals of neurology · 2024Review
- Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow.Alzheimer's research & therapy · 2024Article
- The effects of musicality on brain network topology in the context of Alzheimer's disease and memory decline.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease.Brain communications · 2024Article
- Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight.Nature reviews. Neuroscience · 2023Review
- Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden.Molecular psychiatry · 2023Article
- Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.Human brain mapping · 2023Article
- Depression Is Associated with the Aberration of Resting State Default Mode Network Functional Connectivity in Patients with Amyloid-Positive Mild Cognitive Impairment.Brain sciences · 2023Article
- Amyloid β-based therapy for Alzheimer's disease: challenges, successes and future.Signal transduction and targeted therapy · 2023Review
- Application of data harmonization and tract-based spatial statistics reveals white matter structural abnormalities in pediatric patients with focal cortical dysplasia.Epilepsy & behavior : E&B · 2023Article
- Resting-State Functional Connectivity Changes in Older Adults with Sleep Disturbance and the Role of Amyloid Burden.Research square · 2023Article
- Functional networks in prolonged disorders of consciousness.Frontiers in neuroscience · 2023Review
- Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer's amyloid pathology.Acta neuropathologica communications · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Proteinopathies are key elements in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), with the nature and location of the proteinopathy characterizing much of the disease phenotype. Susceptibility of brain regions to pathology may partly be determined by intrinsic network structure and connectivity. It remains unknown, however, how these networks inform the disease cascade in the context of AD biomarkers, such as beta-amyloid (Aβ), in clinically-normal older adults.The default-mode network (DMN), a prominent intrinsic network, is heavily implicated in AD due to its spatial overlap with AD atrophy patterns and tau deposition. We investigated the influence of baseline Aβ positron emission tomography (PET) signal and intrinsic DMN connectivity on DMN-specific cortical thinning in 120 clinically-normal older adults from the Harvard Aging Brain Study (73 ± 6 years, 58% Female, CDR = 0). Participants underwent
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.