ArticleInfection and immunity1988
Adherence of Candida albicans germ tubes to plastic: ultrastructural and molecular studies of fibrillar adhesins.
Article in Infection and immunity, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 153 citations in OpenAlex.
- Impact of Brief Exposure to Lysozyme and Lactoferrin on Pathogenic Attributes of Oral Candida.International dental journal · 2024Article
- Comparative analysis of hydrophobicity and dentin adhesion ability in Candida albicans strains.Journal of applied oral science : revista FOB · 2024Article
- Functioning of a tripartite lignocellulolytic microbial consortium cultivated under two shaking conditions: a metatranscriptomic study.Biotechnology for biofuels and bioproducts · 2023Article
- Ultrasonic Synthesis and Biomedical Application of MnBiomolecules · 2021Article
- Candida albicans Elicits Pro-Inflammatory Differential Gene Expression in Intestinal Peyer's Patches.Mycopathologia · 2019Article
- In vitro Post-Antifungal Effect of Posaconazole and Its Impact on Adhesion-Related Traits and Hemolysin Production of Oral Candida dubliniensis Isolates.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019Article
- Anti-Candidal Activity and In Vitro Cytotoxicity Assessment of Graphene Nanoplatelets Decorated with Zinc Oxide Nanorods.Nanomaterials (Basel, Switzerland) · 2018Article
- Thigmo Responses: The Fungal Sense of Touch.Microbiology spectrum · 2017Review
- Cellular Components Mediating Coadherence of Candida albicans and Fusobacterium nucleatum.Journal of dental research · 2015Article
- Impact of brief and sequential exposure to nystatin on the germ tube formation and cell surface hydrophobicity of oral Candida albicans isolates from human immunodeficiency virus-infected patients.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Article
- E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis.Antimicrobial agents and chemotherapy · 2012Article
- Fungicidal monoclonal antibody C7 interferes with iron acquisition in Candida albicans.Antimicrobial agents and chemotherapy · 2011Article
- New approach for diagnosis of candidemia based on detection of a 65-kilodalton antigen.Clinical and vaccine immunology : CVI · 2009Article
- Candida albicans adhesion to composite resin materials.Clinical oral investigations · 2009Article
- Candida albicans Adherence to Glass Ionomer Restorative Dental Material.Journal of dental research, dental clinics, dental prospects · 2009Article
- Whole Saliva has a Dual Role on the Adherence of Candida albicans to Polymethylmetacrylate.The open dentistry journal · 2008Article
- Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth.Antimicrobial agents and chemotherapy · 2007Article
- Characterization of switch phenotypes in Candida albicans biofilms.Mycopathologia · 2005Article
- Use of fluorescent lectin probes for analysis of footprints from Pseudomonas aeruginosa MDC on hydrophilic and hydrophobic glass substrata.Applied and environmental microbiology · 2004Article
- Characterization of Candida albicans colony morphological mutants and their hybrids by means of RAPD-PCR, isoenzyme analysis and pathogenicity analysis.Folia microbiologica · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ tubes of Candida albicans produced an additional fibrillar surface layer responsible for enhanced adherence to plastic. The correlation between germination of C. albicans and adherence of germ tubes to a plastic matrix led us to consider the existence of germ tube-specific adhesive components involved in the attachment process. Using concanavalin A-sensitized latex microspheres, we first detected extracellular molecules on the plastic surface after removal of the adherent germ tubes. Electron microscopy confirmed that fibrils of the germ tube involved in cell-substratum interconnections were retained on the plastic surface. Cytochemistry with concanavalin A-gold labeling demonstrated that these fibrillar structures contained mannoproteins. Dithiothreitol and iodoacetamide treatment of washed plastic allowed us to further characterize these fibrillar adhesins. Through analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, two components with molecular weights (MWs) of 68,000 and 60,000 were detected on the plastic surface. The 68,000-MW component appeared to be one of the major constituents of the germ tube surface layers. Biosynthetic labeling experiments performed with L-[35S]methionine revealed two additional proteins: a high-MW component (greater than 200,000), and a 200,000-MW component. These four proteins, strongly labeled on the plastic surface and on the germ tube cell wall layers, were in contrast slightly labeled or even nonidentified in the culture supernatant, suggesting their involvement in germ tube adherence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.