ArticleCell metabolism2020
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System.
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91citing papers in PubMed
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91 citing papers in PubMed, 141 citations in OpenAlex.
- A Unified Framework for Spinal Cord Injury Repair: Metabolic-Nutritional Microenvironment Remodeling, Immune Modulation, and Neural Regeneration.Molecular neurobiology · 2026Review
- Adult central nervous regeneration in Drosophila : Evidence for glial lineage conversion and neurogenic potential post-injury.Neural regeneration research · 2026Article
- Integrative bulk and single-cell transcriptome analyses reveal RNA modification-related biomarkers of spinal cord injury.Neural regeneration research · 2026Article
- l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.The Journal of clinical investigation · 2026Article
- G6PD facilitates axon regeneration via clathrin-mediated endocytosis.The Journal of biological chemistry · 2026Article
- Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.Journal of translational medicine · 2026Article
- Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.Signal transduction and targeted therapy · 2026Review
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
- CREB5 Inhibits Neuronal Ferroptosis via Transactivating ApoL6 to Regulate Lipid Droplet Metabolism After Spinal Cord Injury.CNS neuroscience & therapeutics · 2026Article
- Regulation of Metabolic Rhythms by Glial Clocks.Journal of biological rhythms · 2026Article
- Acetate enhances neuronal plasticity and reduces ischemic brain injury by promoting tau protein lactylation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Article
- Astrocytic Sirt2-Mediated Delactylation Limits Blood-Spinal Cord Barrier Reconstruction after Spinal Cord Injury.Research (Washington, D.C.) · 2026Article
- Beyond Fuel: Exercise-Induced Lactate as a Metabolic-Epigenetic Regulator in Central Nervous System Health and Disease.Biomolecules · 2025Review
- Mechano-bioactive hydrogel bioelectronics for mechanical-electrical-bioenergetic conversion and glia-modulating neural regeneration.Nature communications · 2025Article
- IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Successful axonal regeneration is associated with intraneuronal metabolic reprogramming.iScience · 2025Article
- Effects of age on the response to spinal cord injury: optimizing the larval zebrafish model.Developmental biology · 2025Article
- Suppressing DBNDD2 promotes neuron growth and axon regeneration in adult mammals.Frontiers of medicine · 2025Article
- [Research advances in the inhibitory effect of chondroitin sulfate proteoglycans on axon growth after premature white matter injury and its underlying mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
31 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 7 institutions in 1 country.
Feng LiRaymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Armin SamiShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Harun N NoristaniShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Kieran SlatteryShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Jingyun QiuRaymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Thomas GrovesShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Shuo WangShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Kelly VeerasammyThe City College of New York, CUNY, New York, NY 10031, USA; The City University of New York, Graduate Center, Advanced Science Research Center, Neuroscience Initiative, New York, NY 10031, USA.
Yuki X ChenThe City College of New York, CUNY, New York, NY 10031, USA; The City University of New York, Graduate Center, Advanced Science Research Center, Neuroscience Initiative, New York, NY 10031, USA.
Jorge MoralesThe City College of New York, CUNY, New York, NY 10031, USA.
Paula HaynesHHMI, Chronobiology and Sleep institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Amita SehgalHHMI, Chronobiology and Sleep institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ye HeThe City University of New York, Graduate Center, Advanced Science Research Center, Neuroscience Initiative, New York, NY 10031, USA.
Shuxin LiShriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address: shuxin.li@temple.edu.
Yuanquan SongRaymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: songy2@email.chop.edu.
Temple University · USUniversity of Pennsylvania · USChildren's Hospital of Philadelphia · USCity College of New York · USCity University of New York · USCUNY Advanced Science Research Center · USThe Graduate Center, CUNY · US
Funding
TRAINING PROGRAM IN NEUROPSYCHOPHARMACOLOGY-PREDOCTORALT32MH014654 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1985 to 2021
$5.0MTargeting Atr to promote regeneration and functional recovery after neural injuryR01NS107392 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2018 to 2022
$1.9MDevelop a combinatorial therapy for spinal cord injuryR01NS105961 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN, ZOU, YIMIN · 2018 to 2022
$1.7MCSPG receptors and PTEN in CNS regenerationR01NS079432 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN · 2014 to 2018
$1.7MTherapeutic Strategies for Repairing Optic Nerve InjuryR01EY024575 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN · 2014 to 2017
$1.4MMechanistic studies of novel factors regulating axon regeneration in the PNS/CNSR00NS088211 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2016 to 2018
$728kMechanistic studies of novel factors regulating axon regeneration in the PNS/CNSK99NS088211 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SONG, YUANQUAN · 2014 to 2015
$190kHoward Hughes Medical InstituteNEI NIH HHS R01 EY024575NIMH NIH HHS T32 MH014654NINDS NIH HHS K99 NS088211NINDS NIH HHS R00 NS088211NINDS NIH HHS R01 NS079432NINDS NIH HHS R01 NS105961NINDS NIH HHS R01 NS107392
Abstract
Axons in the mature central nervous system (CNS) fail to regenerate after axotomy, partly due to the inhibitory environment constituted by reactive glial cells producing astrocytic scars, chondroitin sulfate proteoglycans, and myelin debris. We investigated this inhibitory milieu, showing that it is reversible and depends on glial metabolic status. We show that glia can be reprogrammed to promote morphological and functional regeneration after CNS injury in Drosophila via increased glycolysis. This enhancement is mediated by the glia derived metabolites: L-lactate and L-2-hydroxyglutarate (L-2HG). Genetically/pharmacologically increasing or reducing their bioactivity promoted or impeded CNS axon regeneration. L-lactate and L-2HG from glia acted on neuronal metabotropic GABA
Indexed as
AnimalsCentral Nervous SystemDrosophila melanogasterFemaleMiceMice, Inbred C57BLNerve RegenerationNeuroglia2-hydroxyglutarateaxon regenerationcAMPcentral nervous systemfunctional recoveryGABA(B) receptorglialactatemetabolismspinal cord injury
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.