ArticleJournal of leukocyte biology2021
Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes.
Article in Journal of leukocyte biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Innate immune recognition ofInfection and immunity · 2026Article
- Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.International journal of dermatology · 2026Review
- Clinical Significance of Intestinal Fungal Overgrowth: Integrating the Gut Mycobiome into Modern Gastroenterology.Microorganisms · 2026Review
- Advances in Scalp Microbiome Research: Molecular Insights into the Metabolism-Inflammation-Barrier Axis and Dandruff Pathogenesis.Molecules (Basel, Switzerland) · 2026Review
- Scalp Microbiota Dysbiosis in Seborrheic Alopecia and Restoration Following Herbal Extract Shampoo Intervention.Microorganisms · 2026Article
- Mucosal fungal dysbiosis is associated with early postoperative endoscopic recurrence after bowel resection for Crohn's disease.International journal of colorectal disease · 2026Article
- Dual targeting of AMRC12 andTheranostics · 2026Article
- Extracellular vesicles produced byExtracellular vesicles and circulating nucleic acids · 2026Review
- Ecological characteristics of the truncal skin mycobiome in acne and its association with doxycycline exposure.Journal of microbiology (Seoul, Korea) · 2026Article
- Effects of fecal microbiota transplantation on the abundance and diversity of selected fungal and archaeal species in the gut microbiota in the rat model of schizophrenia.Pharmacological reports : PR · 2025Article
- Characterization of Intestinal Mycobiome in Surgical Resections from Inflammatory Bowel Disease Patients: A Deeper Analysis in Complicated Crohn's Disease Phenotypes.Inflammatory bowel diseases · 2025Article
- Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies-A Narrative Review.Biomedicines · 2025Review
- From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences.Molecular neurobiology · 2025Review
- Diagnostic challenges and treatment breakthroughs inFrontiers in cellular and infection microbiology · 2025Article
- Article
- Gut Fungal Microbiota Alterations in Pulmonary Arterial Hypertensive Rats.Biomedicines · 2024Article
- γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.PLoS pathogens · 2024Article
- Influence of tumor mycobiome on cancer pathogenesis (Review).Oncology letters · 2023Review
- Regulatory Ability ofJournal of fungi (Basel, Switzerland) · 2023Article
- The Anti-Atopic Dermatitis Effects ofInternational journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Malassezia spp. are common eukaryotic yeasts that colonize mammalian skin. Recently, the authors and others have observed that Malassezia globosa and Malassezia restricta can be found in the intestines in the context of certain diseases, including Crohn's disease and pancreatic cancer. In order to better understand the nature of innate inflammatory responses to these yeasts, inflammatory responses induced by M. restricta and M. globosa in mouse bone marrow-derived Mϕs (BMDM) and dendritic cells (BMDC) are evaluated. While Malassezia yeasts induce proinflammatory cytokine production from both Mϕs and dendritic cells, the levels of production from BMDC were more pronounced. Both M. restricta and M. globosa activated inflammatory cytokine production from BMDC in large part through Dectin2 and CARD9 signaling, although additional receptors appear to be involved in phagocytosis and activation of reactive oxygen production in response to the yeasts. Both M. restricta and M. globosa stimulate production of pro-IL-1β as well as activation of the NLRP3 inflammasome. NLRP3 inflammasome activation by Malassezia fungi requires SYK signaling, potassium efflux and actin rearrangement. Together, the data further the understanding of the coordinated involvement of multiple innate immune receptors in recognizing Malassezia globosa and Malassezia restricta and orchestrating phagocyte inflammatory and antimicrobial responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.