ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Association Between the Multidimensional Prognostic Index and Mortality During 15 Years of Follow-up in the InCHIANTI Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis.Ageing research reviews · 2021Pooled it
- Trial
- Article
- Usefulness of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) in predicting short- and long-term mortality in community-dwelling older people.Aging clinical and experimental research · 2025Article
- Frailty and anticoagulants in older subjects with atrial fibrillation: the EUROSAF study.Age and ageing · 2023Article
- Older People Hospitalized for COVID-19: Prognostic Role of Multidimensional Prognostic Index and Other Prognostic Scores.Journal of clinical medicine · 2023Article
- The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation: a multicenter, observational, prospective European study (EUROSAF).Annals of medicine · 2022Observational
- Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Validation of Abbreviated Form of the Multidimensional Prognostic Index (MPI): The BRIEF-MPI Project.Clinical interventions in aging · 2022Article
- The challenge of the multifaceted prognosis in the older people and the Multidimensional Prognostic Index.European geriatric medicine · 2021Article
- The Potential Role of miRNAs in Cognitive Frailty.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMultidimensional Prognostic Index (MPI) is recognized as a prognostic tool in hospitalized patients, but data on the value of MPI in community-dwelling older persons are limited. Using data from a representative cohort of community-dwelling persons, we tested the hypothesis that MPI explains mortality during 15 years of follow-up.
methodsA standardized comprehensive geriatric assessment was used to calculate the MPI and to categorize participants in low-, moderate-, and high-risk classes. The results were reported as hazard ratios (HRs) and the accuracy was evaluated with the area under the curve (AUC), with 95% confidence intervals (CIs) and the C-index. We also reported the median survival time by standard age groups.
resultsAll 1453 participants (mean age 68.9 years, women = 55.8%) enrolled in the InCHIANTI study at baseline were included. Compared to low-risk group, participants in moderate (HR = 2.10; 95% CI: 1.73-2.55) and high-risk MPI group (HR = 4.94; 95% CI: 3.91-6.24) had significantly higher mortality risk. The C-index of the model containing age, sex, and MPI was 82.1, indicating a very good accuracy of this model in explaining mortality. Additionally, the time-dependent AUC indicated that the accuracy of the model incorporating MPI to age and sex was excellent (>85.0) during the whole follow-up period. Compared to participants in the low-risk MPI group across different age groups, those in moderate- and high-risk groups survived 2.9-7.0 years less and 4.3-8.9 years less, respectively.
conclusionsIn community-dwelling individuals, higher MPI values are associated with higher risk of all-cause mortality with a dose-response effect.
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