Evidence map›Paper›PMID 32941595›Full record

ArticleThe Journal of experimental medicine2020

Beyond genes and transcription factors: A potential mechanism for the pathogenesis of cerebral cavernous malformations.

William A Muller

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William A MullerNorthwestern University Feinberg School of Medicine, Chicago, IL.
Northwestern University · US

Funding

TWO NOVEL VASCULAR ADHESION MOLECULES: PECAM AND HEC-1R01HL046849 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MULLER, WILLIAM A · 1991 to 2019
$6.7M
PECAM-INDEPENDENT TRANSENDOTHELIAL MIGRATIONR01HL064774 · NHLBI · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MULLER, WILLIAM A · 2000 to 2020
$3.3M
NHLBI NIH HHS R01 HL046849NHLBI NIH HHS R01 HL064774
6 · The paper itself

Abstract

In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20200140) identify a major step in the pathogenesis of cerebral cavernous malformations (CCMs), which at the same time offers insight into potential therapy for this disease.

Indexed as

Hemangioma, Cavernous, Central Nervous SystemADAMTS5 ProteinHumansProteolysisTranscription FactorsVersicansADAMTS5 ProteinADAMTS5 protein, humanTranscription FactorsVersicans

Identifiers

PMID32941595
PMCPMC7537395
OpenAlexW3087475106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.