ArticlePloS one2020
Sepsis and septic shock after craniotomy: Predicting a significant patient safety and quality outcome measure.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Development and validation of an interpretable prediction model for the risk of unplanned reoperation in patients underwent intracranial tumor surgery.Scientific reports · 2026Article
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- Inpatient neurosurgical mortality in germany: a comprehensive analysis of 2023 in-hospital data.Neurosurgical review · 2025Article
- Article
- Association between disseminated cancer and postoperative 30-day mortality in adult patients with brain tumor craniotomy.Frontiers in oncology · 2025Article
- Identifying Common Diagnostic Biomarkers and Therapeutic Targets between COPD and Sepsis: A Bioinformatics and Machine Learning Approach.International journal of chronic obstructive pulmonary disease · 2025Article
- Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection.Nature communications · 2024Article
- Development and external validation of a novel score for predicting postoperative 30‑day mortality in tumor craniotomy patients: A cross‑sectional diagnostic study.Oncology letters · 2024Article
- HemopatchNeurosciences (Riyadh, Saudi Arabia) · 2024Article
- Association between preoperative white blood cell counts and thirty-day surgical mortality after craniotomy in adult intracranial tumor patients.Frontiers in neurology · 2024Article
- Association between preoperative hematocrit and postoperative 30-day mortality in adult patients with tumor craniotomy.Frontiers in neurology · 2023Article
- Article
- Incidence, Risk Factors and Outcomes of Sepsis in Critically Ill Post-craniotomy Patients: A Single-Center Prospective Cohort Study.Frontiers in public health · 2022Article
- Association Between Pre-operative BUN and Post-operative 30-Day Mortality in Patients Undergoing Craniotomy for Tumors: Data From the ACS NSQIP Database.Frontiers in neurology · 2022Article
- Body Mass Index Has a Nonlinear Association With Postoperative 30-Day Mortality in Patients Undergoing Craniotomy for Tumors in Men: An Analysis of Data From the ACS NSQIP Database.Frontiers in endocrinology · 2022Article
- The non-linear association between preoperative platelet to white blood cell ratio and 30-day postoperative mortality in adult tumor craniotomy: a retrospective cohort study.Frontiers in neurologyArticle
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesSepsis and septic shock are important quality and patient safety metrics. This study examines incidence of Sepsis and/or septic shock (S/SS) after craniotomy for tumor resection, one of the most common neurosurgical operations.
methodsMulticenter, prospectively collected data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database was used to identify patients undergoing craniotomy for tumor (CPT 61510, 61521, 61520, 61518, 61526, 61545, 61546, 61512, 61519, 61575) from 2012-2015. Univariate and multivariate logistic regression models were used to identify risk factors for S/SS.
resultsThere were 18,642 patients that underwent craniotomy for tumor resection. The rate of sepsis was 1.35% with a mortality rate of 11.16% and the rate of septic shock was 0.65% with a 33.06% mortality rate versus an overall mortality rate of 2.46% in the craniotomy for tumor cohort. The 30-day readmission rate was 50.54% with S/SS vs 10.26% in those without S/SS. Multiple factors were identified as statistically significant (p <0.05) for S/SS including ascites (OR = 33.0), ventilator dependence (OR = 4.5), SIRS (OR = 2.8), functional status (OR = 2.3), bleeding disorders (OR = 1.7), severe COPD (OR = 1.6), steroid use (OR = 1.6), operative time >310 minutes (OR = 1.5), hypertension requiring medication (OR = 1.5), ASA class ≥ 3 (OR = 1.4), male sex (OR = 1.4), BMI >35 (OR = 1.4) and infratentorial location.
conclusionsThe data indicate that sepsis and septic shock, although uncommon after craniotomy for tumor resection, carry a significant risk of 30-day unplanned reoperation (35.60%) and mortality (18.21%). The most significant risk factors are ventilator dependence, ascites, SIRS and poor functional status. By identifying the risk factors for S/SS, neurosurgeons can potentially improve outcomes. Further investigation should focus on the creation of a predictive score for S/SS with integration into the electronic health record for targeted protocol initiation in this unique neurosurgical patient population.
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