A novel microRNA-based signature predicts prognosis among nasopharyngeal cancer patients.

Tianyu Wang, Jian Wu, Yun Wu, Yin Cheng, Yue Deng, Jianchun Liao, Huanhai Liu, Hu Peng

Abstract read

In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Development and internal validation of a nomogram based on peripheral blood inflammatory markers for predicting prognosis in nasopharyngeal carcinoma.Cancer medicine · 2024
Article
Identification and analysis of lipid metabolism-related genes in allergic rhinitis.Lipids in health and disease · 2023
Article
MiRNA signatures in nasopharyngeal carcinoma: molecular mechanisms and therapeutic perspectives.American journal of cancer research · 2023
Review
Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs.International journal of molecular sciences · 2022
Review
Multiple microRNA signature panel as promising potential for diagnosis and prognosis of head and neck cancer.Molecular biology reports · 2022
Review
A novel three-microRNA signature for predicting survival in patients with nasopharyngeal carcinoma.Journal of dental sciences · 2022
Article
A Five-MicroRNA Signature Predicts the Prognosis in Nasopharyngeal Carcinoma.Frontiers in oncology · 2021
Article
miR-137 Inhibition of the Invasion, Metastasis, and Epithelial-Mesenchymal Transition of Nasopharyngeal Cancer by Regulating KDM1A.Journal of oncology · 2021
Article

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Tianyu WangDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Jian WuDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Yun WuDepartment of Otorhinolaryngology-Head and Neck Surgery, Jiangsu Taizhou People's Hospital, Taizhou 225300, China; *Tianyu Wang, Jian Wu and Yun Wu are contributed equally to this paper.

Yin ChengDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Yue DengDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Jianchun LiaoDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Huanhai LiuDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Hu PengDepartment of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.ORCID 0000-0002-5799-9703

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementNasopharyngeal cancer is one of the most common malignant tumors in the head and neck. Identification of promising miRNA biomarkers might benefit a lot to the detection of nasopharyngeal carcinoma. A three-miRNA signature (has-miR-142-3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. The model has better clinical independence and has better clinical prediction effect when combined with clinical characteristics. Our results revealed that a three-miRNA signature was a potential novel prognostic biomarker for nasopharyngeal carcinoma.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticArea Under CurveHumansKaplan-Meier EstimateMicroRNAsNasopharyngeal NeoplasmsPrognosisReproducibility of ResultsMicroRNAsarea under the curveGene Expression OmnibusmiRNA signatureNasopharyngeal cancer

Identifiers

PMID32941074

DOI10.1177/1535370220958680

PMCPMC7797999

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.