ArticlePain and therapy2020
Real-World Evidence in Prescription Medication Use Among U.S. Adults with Neck Pain.
Article in Pain and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High-Intensity Laser Therapy and Stretching Exercises on Chronic Non-Specific Neck Pain: Findings From a Clinical Trial
Effects of Rhomboids Strength Training Regime on Pain, Craniovertebral Angle and Disability Among Patients With Upper Crossed Syndrome
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Modulatory effects of acupuncture on raphe nucleus-related brain circuits in patients with chronic neck pain: A randomized neuroimaging trial.CNS neuroscience & therapeutics · 2024Trial
- Patients with cervical degenerative disease have greater post-operative opioid use and reoperation following shoulder instability procedures.JSES reviews, reports, and techniques · 2026Article
- Association between spinal manipulative therapy and cervical artery dissection in patients with neck pain or headache: a retrospective cohort study.Chiropractic & manual therapies · 2026Article
- Efficacy and Safety of Traditional Chinese Medicine Exercise Versus Oral Medication in the Treatment of Neck Pain: Study Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2026Article
- Barriers and facilitators for the implementation of Tuina (Jingjin) for neck pain in primary care settings in China: a qualitative study protocol.Frontiers in medicine · 2026Article
- Efficacy and safety of the thumbtack needle for neck pain: a systematic review and meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Temporal trends in neck pain prevalence among adolescents and young adults aged 10-24 from 1990 to 2019.Archives of medical science : AMS · 2025Article
- Optimal Information for Chronic Pain (OICP): Delphi Consensus on Patient Assessment and Interventional Techniques.Journal of pain research · 2025Article
- Effectiveness of Acupuncture for Neck Pain: Systematic Review and Meta‑analysis with Trial Sequential Analysis.Journal of pain research · 2025Review
- OPAL trial: challenging the use of opioid analgesics for acute low back pain and neck pain: a milestone in evidence-based medicine.Annals of medicine and surgery (2012) · 2023Article
- Effect of acupuncture on pain and substance P levels in middle-aged women with chronic neck pain.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
introductionNeck pain is a common condition that leads to serious pain, disability, and increased healthcare costs worldwide. Pharmacotherapy is one of the most common strategies to reduce neck pain in patients. The aim of this study was to analyze the real-world pattern of drugs prescribed for patients with neck pain in the USA.
methodsData on individuals who reported current neck pain in the 2009-2010 US National Health and Nutrition Examination Survey (NHANES) and with a history of persistent pain for at least 6 weeks or 3 months were extracted from the NHANES database. Those included in the study were divided into three groups based on the duration of pain: the without neck pain group (Group A); subacute group (Group B) with a history of 6 weeks of neck pain; and the chronic neck pain group (Group C) with a history of 3 months of neck pain. The use and duration of medication prescribed for Group A, B, and C patients were compared.
resultsThe analysis revealed that opioid use was significantly more prevalent in the subacute and chronic neck pain group than in the without neck pain group (Group A) (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 2.07-8.52 and aOR 7.00, 95% CI 4.32-11.33, respectively). The factors strongly associated with higher opioid use included older age, low education level, and low family income. In the chronic neck group, opioids, followed in decreasing order of frequency by acetaminophen and nonsteroidal anti-infammatory drugs, were the most common analgesics used in combination with other analgesics.
conclusionOur analysis of the data shows that the long-term excessive use of opioids and the underutilization of other analgesics are two major issues in the treatment of neck pain in the USA. Possible improvements include improved education of patients by healthcare professionals on the use of opioids and more consideration given to non-pharmacotherapy options. Our results reveal the potential problem in pharmacotherapy choices for neck pain treatment and may help improve the current clinical practice in the USA and other countries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.