Evidence map›Paper›PMID 32940875›Full record

ArticleJournal of molecular neuroscience : MN2021

Severe Zinc Deficiency Causes the Loss and Apoptosis of Olfactory Ensheathing Cells (OECs) and Olfactory Deficit.

Yu Jiang, Lingqi Gu, Zilin Zhang, Jianya Zhao, Chunhua Wan

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Association between dietary zinc intake and olfactory dysfunction: a study based on the NHANES database.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Relationship between the severity of olfactory dysfunction and serum zinc levels.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yu Jiang *Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, No. 9, Seyuan Road, Nantong, 226001, People's Republic of China.
Lingqi Gu *Department of Pharmacy, Nantong Maternal and Child Health Hospital, 399 Century Avenue, Nantong, 226018, Jiangsu, China.
Zilin ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, No. 9, Seyuan Road, Nantong, 226001, People's Republic of China.
Jianya ZhaoDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, No. 9, Seyuan Road, Nantong, 226001, People's Republic of China.
Chunhua WanDepartment of Nutrition and Food Hygiene, School of Public Health, Nantong University, No. 9, Seyuan Road, Nantong, 226001, People's Republic of China. Chwan@ntu.edu.cn.ORCID http://orcid.org/0000-0003-2896-0989
Nantong University · CN

Funding

Young Scientists Fund 81300720
6 · The paper itself

Abstract

Dietary zinc deficiency may lead to olfactory deficits, whose mechanism remains largely elusive. Olfactory ensheathing cells (OECs), a type of glial cells that support the function and neurogenesis in the olfactory bulb (OB), may play a pivotal role in the maintenance of the olfactory system. In the present study, we established a rat model of dietary zinc deficiency and found that severe zinc deficiency, but not marginal zinc deficiency, caused significantly reduced food intake, growth retardation, and apparent olfactory deficit in growing rats. We showed that severe zinc deficiency resulted in the loss of OECs in the olfactory nerve layer (ONL) of the olfactory bulb. In addition, we revealed that the number of TUNEL-positive cells increased markedly in the region, suggesting an involvement of apoptotic cell death in zinc deficiency-induced loss of OECs. Moreover, we found that treatment with zinc chelator N,N,N'N',-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) triggered the apoptosis of in vitro-cultured primary OECs. The apoptosis of OECs was correlated with significantly elevated expression of p53. Importantly, TUNEL and CCK-8 assays both demonstrated that treatment with p53 antagonist pifithrin-α (PFT-α) markedly attenuated TPEN-induced OEC apoptosis. These findings implicated that p53-triggered apoptosis of OECs might play an integral role in zinc deficiency-induced olfactory malfunction.

Indexed as

ApoptosisSmellAnimalsCells, CulturedChelating AgentsEthylenediaminesFemaleNeurogliaOlfactory BulbRatsRats, Sprague-DawleyTumor Suppressor Protein p53ZincChelating AgentsEthylenediaminesN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamineTumor Suppressor Protein p53ZincApoptosisOlfactory deficitOlfactory ensheathing cellsZinc deficiency

Identifiers

PMID32940875
OpenAlexW3087141726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.