Evidence map›Paper›PMID 32940797›Full record

ArticleJournal of neurology2021

A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection.

Fabio Giuseppe Masuccio, Massimo Barra, Geda Claudio, Solaro Claudio

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 9 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 9 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  5. COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
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  17. Case of acute onset ataxia caused byBMJ case reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fabio Giuseppe MasuccioDepartment of Neurorehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, SNC, 13040, Moncrivello, VC, Italy. fgmasuccio@yahoo.it.ORCID http://orcid.org/0000-0003-2346-6674
Massimo BarraDepartment of Neurology, ASL TO4 Chivasso, C.so G. Ferraris 3, Chivasso, Italy.
Geda ClaudioDepartment of Neurology, ASL TO4 Ivrea, P.za Credenza 2, Ivrea, Italy.
Solaro ClaudioDepartment of Neurorehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, SNC, 13040, Moncrivello, VC, Italy.
Ospedale Civile Di Ivrea · ITTrivella (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barrè Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with "ground glass opacities", suggesting Coronavirus disease (COVID-19). The patient exhibited three negative reverse-transcription polymerase chain reaction (RT-PCR) nasopharyngeal swabs, while SARS-CoV-2 IgG was found in plasma. The electrophysiological examination demonstrated an AMAN and the spinal cord Magnetic Resonance Imaging (MRI) showed a T2-weighted hyperintense lesion in the posterior part of the spinal cord at the C7-D1 levels. Furthermore, anti-GD1b IgM was detected. GBS and myelitis could exceptionally develop simultaneously. Our findings reasonably support a causality link between COVID-19 and the neurological symptoms, suggesting a post-infective autoimmune reaction.

Indexed as

COVID-19Guillain-Barre SyndromeMyelitisAntibodies, ViralHumansSARS-CoV-2Antibodies, ViralAMANAntiganglioside antibodiesGuillain-barrè syndromeMyelitisSARS-CoV-2

Identifiers

PMID32940797
PMCPMC7497229
OpenAlexW3084483616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.