ArticleInternational orthopaedics2021
Subchondral bone cysts regress after correction of malalignment in knee osteoarthritis: comply with Wolff's law.
Article in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Navigation-Assisted Extra-articular Approach for Curettage of a Subchondral Bone Cyst of the Humeral Trochlea.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- AOZORA study: 3-year interim analysis of safety and joint health in pediatric people with hemophilia A receiving emicizumab prophylaxis.Research and practice in thrombosis and haemostasis · 2025Article
- Baseline loss of knee extension is associated with regional MRI progression in knee osteoarthritis: a retrospective longitudinal cohort study-data from the osteoarthritis initiative.Rheumatology international · 2025Article
- Assessment and quantification of ipsilateral and contralateral ankle joint alignment changes after unilateral total knee arthroplasty for knee osteoarthritis with varus deformity: a retrospective cohort study.Knee surgery & related research · 2025Article
- Periosteal distraction as a new surgical technique for the treatment of senile diabetic foot: A retrospective case analysis.Medicine · 2025Article
- Pathological progression of osteoarthritis: a perspective on subchondral bone.Frontiers of medicine · 2024Review
- Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism.Journal of cellular and molecular medicine · 2024Review
- A new technique of autologous bone grafting for open-wedge high tibial osteotomy.Frontiers in surgery · 2024Article
- Biomechanical analysis of different techniques for residual bone defect from tibial plateau bone cyst in total knee arthroplasty.Frontiers in bioengineering and biotechnology · 2024Article
- Lateral meniscus with tears or with histologic calcification does not increase the risk of lateral osteoarthritis after medial unicompartmental arthroplasty.International orthopaedics · 2023Article
- Subchondral Bone Cyst Development in Osteoarthritis: From Pathophysiology to Bone Microarchitecture Changes and Clinical Implementations.Journal of clinical medicine · 2023Review
- Osteotomies around the knee lead to corresponding frontal realignment of the ankle.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Osteoarthritis: an ancient disease, an unsolved conundrum.International orthopaedics · 2021Article
- Cyst formation in the subchondral bone following cartilage repair.Clinical and translational medicine · 2020Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to discuss the mechanical function of subchondral bone cysts and its relationship with Wolff's law.
methodsOne hundred forty symptomatic knees (120 patients) with osteoarthritis were subjected to MRI before high tibial osteotomy (HTO). Subchondral bone cysts (SBCs) were detected on 72 knees of these 140 knees. SBCs, bone marrow lesion (BML), and hip-knee-ankle (HKA) axis were measured by using validated methods. After HTO, the evolution of cysts was evaluated on MRI performed with a five year follow-up on the 72 knees with pre-operative cysts.
resultsAt baseline, 70 (97%) of these 72 knees had a BML surrounding the SBCs; the maximum cyst volume was 874 mm
conclusionRegression of subchondral bone cysts may be related to restoration of an appropriate load at the subchondral bone. With applying poroelasticity to bone mechaincs, this finding may suggest that SBCs and BMLs may be a physiological adaptation to mechanic overload. More basic research is needed to prove this matter.
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