ArticleBrain : a journal of neurology2020
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Exploring Language Impairment in Catalan-Dominant Bilinguals with Primary Progressive Aphasia: Preliminary Data.Brain sciences · 2025Article
- Data-driven classification of narrative speech characteristics in stroke aphasia distinguishes neurological and strategic contributions.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- An Introduction to Machine Learning for Speech-Language Pathologists: Concepts, Terminology, and Emerging Applications.Perspectives of the ASHA special interest groups · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Role of pause duration in primary progressive aphasia.Aphasiology · 2025Article
- Artificial intelligence classifies primary progressive aphasia from connected speech.Brain : a journal of neurology · 2024Article
- Graded Multidimensional Clinical and Radiologic Variation in Patients With Alzheimer Disease and Posterior Cortical Atrophy.Neurology · 2024Observational
- Connected Speech Fluency in Poststroke and Progressive Aphasia: A Scoping Review of Quantitative Approaches and Features.American journal of speech-language pathology · 2024Article
- Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study.Alzheimer's research & therapy · 2024Article
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dissociating reading and auditory comprehension in persons with aphasia.Brain communications · 2024Article
- Using Generative Artificial Intelligence to Classify Primary Progressive Aphasia from Connected Speech.medRxiv : the preprint server for health sciences · 2023Article
- The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.Alzheimer's research & therapy · 2023Article
- Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023Article
- Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia.Brain communications · 2023Article
- Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia.Brain : a journal of neurology · 2022Review
- A 'Mini Linguistic State Examination' to classify primary progressive aphasia.Brain communications · 2022Article
- Unclassified fluent variants of primary progressive aphasia: distinction from semantic and logopenic variants.Brain communications · 2022Article
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Abstract
Language impairments caused by stroke (post-stroke aphasia, PSA) and neurodegeneration (primary progressive aphasia, PPA) have overlapping symptomatology, nomenclature and are classically divided into categorical subtypes. Surprisingly, PPA and PSA have rarely been directly compared in detail. Rather, previous studies have compared certain subtypes (e.g. semantic variants) or have focused on a specific cognitive/linguistic task (e.g. reading). This study assessed a large range of linguistic and cognitive tasks across the full spectra of PSA and PPA. We applied varimax-rotated principal component analysis to explore the underlying structure of the variance in the assessment scores. Similar phonological, semantic and fluency-related components were found for PSA and PPA. A combined principal component analysis across the two aetiologies revealed graded intra- and intergroup variations on all four extracted components. Classification analysis was used to test, formally, whether there were any categorical boundaries for any subtypes of PPA or PSA. Semantic dementia formed a true diagnostic category (i.e. within group homogeneity and distinct between-group differences), whereas there was considerable overlap and graded variations within and between other subtypes of PPA and PSA. These results suggest that (i) a multidimensional rather than categorical classification system may be a better conceptualization of aphasia from both causes; and (ii) despite the very different types of pathology, these broad classes of aphasia have considerable features in common.
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