Trial reportBrain and behavior2020
High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) improves symptoms and autonomic function for insomnia: A randomized, placebo-controlled clinical trial.
Trial report in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Effectiveness of Sound-Based Interventions for Improving Functional Outcomes in Children: A Systematic Review of the Evidence.Occupational therapy international · 2025Pooled it
- A systematic review and meta-analysis of acoustic stimulation in the treatment of insomnia.Frontiers in neuroscience · 2025Pooled it
- Randomized, controlled clinical trial of acoustic stimulation to reduce postconcussive symptoms.Annals of clinical and translational neurology · 2024Trial
- High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) improves symptoms and autonomic function for insomnia: A randomized, placebo-controlled clinical trial.Brain and behavior · 2020Trial
- Age Differences in Factors Associated With Insomnia Severity: A Comparative Study of Questionnaire Scores and Heart Rate Variability Parameters.Depression and anxiety · 2026Article
- Brain dynamic audio stimulation for subjective sleep disturbances in healthcare professionals: a single-arm pilot feasibility study.Frontiers in neuroscience · 2026Article
- Traumatic brain injury and sleep in military and veteran populations: A literature review.NeuroRehabilitation · 2024Review
- Understanding societal challenges: a NeurotechFrontiers in neuroscience · 2024Article
- Article
- Cereset Research Standard Operating Procedures for Insomnia: A Randomized, Controlled Clinical Trial.Global advances in integrative medicine and healthArticle
- Randomized Controlled Trial of Acoustic Neuromodulation to Enhance Well-Being in Healthcare Workers.Global advances in integrative medicine and healthArticle
- What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
introductionEffective insomnia interventions that also address autonomic dysregulation are lacking. We evaluate high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM
methodsOne hundred and seven adults (mean age 45.7, SD ± 5.6, 73 women), with Insomnia Severity Index (ISI) scores of ≥15, received ten, 90-min sessions of HIRREM, with tones linked to brainwaves (LB, 56), or random tones not linked to brainwaves (NL, 51), as an active, sham placebo. Outcomes were obtained at enrollment (V1), 1-7 days (V2), 8-10 weeks (V3), and 16-18 weeks (V4) after intervention. Primary outcome was differential change in ISI from V1 to V3. Secondary measures assessed depression (BDI), anxiety (BAI), quality of life (EQ-5D), and a sleep diary. Ten minute recordings of HR and BP allowed analysis of heart rate variability (HRV) and baroreflex sensitivity (BRS).
resultsOf 107 randomized, 101 completed the intervention. Intention-to-treat analysis (107) of change from V1 to V3 revealed a mean reduction of ISI in NL of -4.93 (SE ± 0.76) points, with additional, significant reduction of -2.05 points (0.74) in LB (total reduction of -6.98, p = .045). Additional reduction of -2.30 points (0.76) was still present in the LB at V4 (p = .058). Total ISI reduction from V1 to V4 was -5.90 points for NL and -7.93 points in LB. There were group differences (p < .05) for multiple HRV and BRS measures (rMSSD, SDNN, HF alpha, and Seq ALL), as well as total sleep time, sleep onset latency, and sleep efficiency. There were no serious adverse events.
conclusionsResults of this controlled clinical trial showed clinically relevant reduction of insomnia symptoms with HIRREM, over, and above an active, sham control, with associated, durable improvement in autonomic cardiovascular regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.