Evidence map›Paper›PMID 32940099›Full record

ArticleThe Journal of international medical research2020

Long noncoding RNA MCM3AP antisense RNA 1 is downregulated in chronic obstructive pulmonary disease and regulates human bronchial smooth muscle cell proliferation.

Kaishun Zhao, Chunlin Tu, Kaiyi Liang, Ying Li, Yanfang Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Long Noncoding RNAFrontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kaishun Zhao
Chunlin Tu
Kaiyi LiangDepartment of Radiology, Jiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, P. R. China.
Ying LiDepartment of Respiratory Medicine, Jiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, P. R. China.
Yanfang YuDepartment of Respiratory Medicine, Jiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-7061-7311
Jiading District Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the involvement of MCM3AP antisense RNA 1 (MCM3AP-AS1) in chronic obstructive pulmonary disease (COPD).

methodsThe expression levels of plasma MCM3AP-AS1 in COPD patients and healthy controls were measured by quantitative PCR before treatment and at 3 months after the initiation of treatment (post-treatment) from COPD patients. The role of MCM3AP-AS1 in regulating the proliferation of human bronchial smooth muscle cells (HBSMCs) was explored by a cell proliferation assay.

resultsWe found that MCM3AP-AS1 expression was downregulated in the plasma of COPD patients compared with controls. Among controls, MCM3AP-AS1 expression was lower in smokers than never-smokers. A 3-year follow-up study showed that, among smokers, patients with low MCM3AP-AS1 expression showed a higher incidence of COPD. After treatment for COPD, MCM3AP-AS1 expression significantly increased. The cell proliferation assay showed that MCM3AP-AS1 overexpression decreased the proliferation rate of HBSMCs. MCM3AP-AS1 silencing had the opposite effect.

conclusionsMCM3AP-AS1 appears to be downregulated in COPD and to predict its occurrence. MCM3AP-AS1 regulates the proliferation of HBSMCs to participate in airway remodeling.

Indexed as

AcetyltransferasesIntracellular Signaling Peptides and ProteinsMicroRNAsPulmonary Disease, Chronic ObstructiveRNA, Long NoncodingCell ProliferationFemaleFollow-Up StudiesHumansMaleMyocytes, Smooth MuscleAcetyltransferasesIntracellular Signaling Peptides and ProteinsMCM3AP protein, humanMicroRNAsRNA, Long Noncodingairway remodelingChronic obstructive pulmonary diseasehuman bronchial smooth muscle cellsMCM3AP antisense RNA 1proliferationsmoking

Identifiers

PMID32940099
PMCPMC7503009
OpenAlexW3087449345

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.