ArticleBrain and behavior2020
Modulation of behavioral responses and CA1 neuronal death by nitric oxide in the neonatal rat's hypoxia model.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Behavioral and physiological benefits of alpha-pinene in adult rats experiencing chronic stress: A focus on depression and oxidative stress.IBRO neuroscience reports · 2025Article
- Coenzyme Q10 Modulates BDNF and it is Regulating Non-coding RNAs to Attenuate Motor Deficits and Neurodegeneration in Cerebellum of Cuprizone-Induced Demyelination Rat Model.Molecular neurobiology · 2025Article
- Impact of hypoxia on the hippocampus: A review.Medicine · 2025Review
- Possibility of Using NO Modulators for Pharmacocorrection of Endothelial Dysfunction After Prenatal Hypoxia.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures.IBRO neuroscience reports · 2024Article
- Article
- The effects of MEPaL on oxidative stress and motor function in the rats affected by prenatal hypoxia.Brain and behavior · 2024Article
- Seipin overexpression attenuates cerebral ischemia-reperfusion injury via preventing apoptosis and autophagy.Brain and behavior · 2023Article
- Altered Blood Molecular Markers of Cardiovascular Function in Rats after Intrauterine Hypoxia and Drug Therapy.Current issues in molecular biology · 2023Article
- Cardioprotective Activity of Pharmacological Agents Affecting NO Production and Bioavailability in the Early Postnatal Period after Intrauterine Hypoxia in Rats.Biomedicines · 2023Article
- Modulation of behavioral responses and CA1 neuronal death by nitric oxide in the neonatal rat's hypoxia model.Brain and behavior · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionNeonatal hypoxia leads to cognitive and movement impairments that might persist throughout life. Hypoxia impairs hippocampal blood circulation and metabolism. The exact mechanisms underlying hypoxia-induced memory impairment are not fully understood. Nitric oxide (NO) is a key neuromodulator that regulates cerebral blood flow. In this study, we aimed to evaluate the possible role of NO on behavioral and histomorphometric changes in the hippocampus following hypoxia in neonate rats. MATERIAL AND
methodsNeonate male rats (n = 28) were randomly divided into 4 groups: control, hypoxia, hypoxia plus L-NAME (20 mg/kg), and hypoxia plus L-arginine (200 mg/kg). Drugs were injected intraperitoneally for seven consecutive days. Hypoxia was induced by keeping rats in a hypoxic chamber (7% oxygen and 93% nitrogen intensity). Ten to 14 days after hypoxia, behavioral changes were measured using a shuttle box, a rotarod, and an open field test. The histological changes in the hippocampus were measured using H&E and Nissl staining methods.
resultsFindings showed that hypoxia caused significant atrophy in the hippocampus. Furthermore, the administration of L-NAME decreased the atrophy of the hippocampus in comparison with the hypoxic group. Behavioral results showed that hypoxia impaired memory performance and motor activity responses. Additionally, the administration of L-NAME improved behavioral performance in a significant manner compared with the hypoxic group.
conclusionsHypoxia damaged the neurons of hippocampal CA1 region and induced memory impairment. The NOS inhibitor, L-NAME, significantly attenuated the negative effects of hypoxia on behavior and observed changes in the hippocampus.
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