Evidence map›Paper›PMID 32939714›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Live Imaging of Epithelial-Mesenchymal Transition in Mesoderm Cells of Gastrulating Drosophila Embryos.

Lingkun Gu, Mo Weng

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lingkun GuSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA.
Mo WengSchool of Life Sciences, University of Nevada, Las Vegas, NV, USA. mo.weng@unlv.edu.
University of Nevada, Las Vegas · US

Funding

Mechanosensitive remodeling of adherens junctions during snail-driven EMTR00HD088764 · NICHD · UNIVERSITY OF NEVADA LAS VEGAS · PI WENG, MO · 2018 to 2020
$742k
NICHD NIH HHS R00 HD088764
6 · The paper itself

Abstract

Epithelial-mesenchymal transitions (EMTs) drive the generation of cell diversity during both evolution and development. More and more evidence has pointed to a model where EMT is not a binary switch but a reversible process that can be stabilized at intermediate states. Despite our vast knowledge on the signaling pathways that trigger EMT, we know very little about how EMT happens in a step-wise manner. Live imaging of cells that are undergoing EMT in intact, living, animals will provide us valuable insights into how EMT is executed at both the cellular and molecular levels and help us identify and understand the intermediate states. Here, we describe how to image early stages of EMT in the mesoderm cells of live Drosophila melanogaster embryos and how to image contractile myosin that suspends EMT progression.

Indexed as

AnimalsDrosophila melanogasterEmbryonic DevelopmentEpithelial-Mesenchymal TransitionEpitheliumGastrulaGastrulationHumansMesodermMolecular ImagingSignal TransductionAdherens junctionsDrosophila embryoEpithelial-mesenchymal transitionLive imagingMyosin

Identifiers

PMID32939714
PMCPMC9870095
OpenAlexW3087557547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.