Evidence map›Paper›PMID 32939625›Full record

ArticleBehavior genetics2021

Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity.

Aimee L Thomas, Luke M Evans, Michaela D Nelsen, Elissa J Chesler, Matthew S Powers, Winona C Booher, Christopher A Lowry, John C DeFries, Marissa A Ehringer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aimee L Thomas *Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Luke M Evans *Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.
Michaela D NelsenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Elissa J CheslerJackson Labs, Bar Harbor, ME, USA.
Matthew S PowersDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Winona C BooherDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
John C DeFriesDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Marissa A EhringerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. Marissa.Ehringer@colorado.edu.ORCID http://orcid.org/0000-0003-0388-7375

Funding

Estimating the genetic and environmental architecture of psychiatric disordersR01MH100141 · NIMH · UNIVERSITY OF COLORADO · PI KELLER, MATTHEW CHARLES · 2013 to 2022
$5.3M
Data Structures, Algorithms and Tools for Ontological DiscoveryR01AA018776 · NIAAA · JACKSON LABORATORY · PI CHESLER, ELISSA J · 2010 to 2019
$3.9M
Mycobacterium vaccae and stress resilience: Neural mechanismsR21MH116263 · NIMH · UNIVERSITY OF COLORADO · PI FRANK, MATTHEW G, LOWRY, CHRISTOPHER A · 2018 to 2019
$424k
NIAAA NIH HHS R01 AA018776NIMH NIH HHS R01 MH100141NIMH NIH HHS R21 MH116263
6 · The paper itself

Abstract

We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA variants that differed between their BALB/cJ and C57BL/6J parental strains. Next, we assessed genome-wide sharing (3,678,826 variants) both between and within the High and Low Activity strains. Results suggested that about 10% of these DNA variants may be associated with OFA, and clearly demonstrated its polygenic nature. Finally, we conducted bioinformatic analyses of functional genomics data from mouse, rat, and human to refine previously identified quantitative trait loci (QTL) for anxiety-related measures. This combination of sequence analysis and genomic-data integration facilitated refinement of previously intractable QTL findings, and identified possible genes for functional follow-up studies.

Indexed as

AnimalsAnxietyAnxiety DisordersChromosome MappingComputational BiologyDisease Models, AnimalExome SequencingGenomicsGenotypeHumansMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred StrainsOpen Field TestPhenotypeAnxiety phenotypesGeneWeaverHigh and Low Activity strainsQuantitative trait lociWhole-genome sequencing

Identifiers

PMID32939625
PMCPMC7854991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.