Evidence map›Paper›PMID 32939447›Full record

ArticleJHEP reports : innovation in hepatology2020

Nuclear deformation mediates liver cell mechanosensing in cirrhosis.

Sergi Guixé-Muntet, Martí Ortega-Ribera, Cong Wang, Sonia Selicean, Ion Andreu, Jenny Z Kechagia, Constantino Fondevila, Pere Roca-Cusachs, Jean-François Dufour, Jaime Bosch and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Sinusoidal communication in chronic liver disease.Clinical and molecular hepatology · 2025
    Review
  14. Mechanisms and implications of recompensation in cirrhosis.JHEP reports : innovation in hepatology · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Mechanobiology of portal hypertension.JHEP reports : innovation in hepatology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Sergi Guixé-MuntetDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Martí Ortega-RiberaLiver Vascular Biology Research Group, Hepatic Hemodynamic Laboratory, IDIBAPS Biomedical Research Institute, CIBEREHD, Barcelona, Spain.
Cong WangDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Sonia SeliceanDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Ion AndreuInstitute for Bioengineering of Catalonia, Barcelona Institute of Technology, University of Barcelona, Barcelona, Spain.
Jenny Z KechagiaInstitute for Bioengineering of Catalonia, Barcelona Institute of Technology, University of Barcelona, Barcelona, Spain.
Constantino FondevilaLiver Surgery, Hospital Clinic de Barcelona, CIBEREHD, Barcelona, Spain.
Pere Roca-CusachsInstitute for Bioengineering of Catalonia, Barcelona Institute of Technology, University of Barcelona, Barcelona, Spain.
Jean-François DufourDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Jaime BoschDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Annalisa BerzigottiDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
Jordi Gracia-SanchoDepartment of Biomedical Research, University of Bern, Bern, Switzerland.
University of Bern · CHInstitute for Bioengineering of Catalonia · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversity Hospital of Bern · CHCentro de Investigación Biomédica en Red · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsLiver stiffness is increased in advanced chronic liver disease (ACLD) and accurately predicts prognosis in this population. Recent data suggest that extracellular matrix stiffness

methodsHepatocytes, hepatic stellate cells, and liver sinusoidal endothelial cells were isolated from healthy rats or rats with cirrhosis (carbon tetrachloride or thioacetamide), and cultured on polyacrylamide gels with different physiologically relevant stiffness for 72 h.

resultsAll cell types of rats with cirrhosis cultured at low stiffness showed a significant phenotype amelioration

conclusionsThe environment's stiffness LAY SUMMARY: During cirrhosis, the liver becomes scarred, stiff, and unable to perform its normal functions efficiently. In this study, we demonstrated that cells from diseased (stiff) livers recovered their functionality when placed in a soft environment (as that of a healthy liver). Furthermore, treatments aimed at

Indexed as

ACLD, advanced chronic liver diseaseCd, cytoskeleton disruptorChronic liver diseaseDN-KASH, dominant negative nesprin peptide containing a KASH domainECM, extracellular matrixeNOS, endothelial nitric oxide synthaseHepatocyteHNF4α, hepatocyte nuclear factor 4αHSCHSC, hepatic stellate cellKASH, Klarsicht/abnormal nuclear anchorage-1/Syne homologyLamb1, laminin b1LSECLSEC, liver sinusoidal endothelial cellStiffnessTAA, thioacetamideα-SMA, α-smooth muscle actin

Identifiers

PMID32939447
PMCPMC7479345
OpenAlexW3042456002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.