ArticleClinical neurophysiology practice2020
Jitter evaluation in denervation and reinnervation in 32 cases of chronic radiculopathy.
Article in Clinical neurophysiology practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- [EMG phenomena of myogenic hyperexcitability].Der Nervenarzt · 2024Review
- The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability.Clinical neurophysiology practice · 2024Review
- Electrophysiological evaluation of the neuromuscular junction: a brief review.Arquivos de neuro-psiquiatria · 2023Review
- Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems.Ageing research reviews · 2023Review
- Concentric needle jitter: Reference values in stimulatedFrontiers in neurology · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo measure the jitter parameters in muscles with denervation/reinnervation in 32 chronic radiculopathy cases.
methodsMeasurements were done in chronic denervated muscles by voluntary and electrical activation using a concentric needle electrode.
resultsMean jitter was abnormal in 87.5% (mean 49.2 µs) and 81.25% (mean 36.8 µs), for voluntary and electrical activation. In muscles with fibrillation potentials (FPs), the mean jitter was abnormal in all cases, and impulse blocking was frequent (53.4-92.3%). In muscles without FPs, the mean jitter was abnormal in 78.9% for voluntary activation and 68.4% for electrical activation. No correlation was found between jitter and motor unit action potential amplitude.
conclusionThe muscles with FPs were associated with the immature spread of acetylcholine receptors (AChRs) throughout the muscle membrane. Conversely, the neuromuscular junctions (NMJs) assemble may be repressed by the already reinnervated muscles. For those, higher jitter may be due to the persistence of atrophic fibers expressing neonatal myosin heavy chain (MHC) and immaturity of NMJ composting instead of the overspread of immature AChRs. SIGNIFICANCE: Jitter measurement must be avoided in chronic denervated muscles, regardless of FPs' presence. The activity of reinnervated muscle could maintain neonatal MHC and repress new NMJs development.
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