Evidence map›Paper›PMID 32939420›Full record

ArticleClinical neurophysiology practice2020

Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation.

Mitchell B Locke, Stephen L Toepp, Claudia V Turco, Diana H Harasym, Michel P Rathbone, Michael D Noseworthy, Aimee J Nelson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mitchell B LockeDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Stephen L ToeppDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Claudia V TurcoDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Diana H HarasymSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Michel P RathboneDepartment of Medicine, Division of Neurology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
Michael D NoseworthySchool of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Aimee J NelsonDepartment of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
McMaster University · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS).

methodsFifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex.

resultsCortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere.

conclusionsThese data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies. SIGNIFICANCE: This study provides novel evidence of lasting neurophysiological changes in PCS.

Indexed as

ConcussionInhibitionMotor cortexPost-concussion syndromeTranscranial magnetic stimulation

Identifiers

PMID32939420
PMCPMC7479250
OpenAlexW3047331142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.