Evidence map›Paper›PMID 32939381›Full record

ArticleData in brief2020

Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset.

Thorsten Langer, Eva Clemens, Linda Broer, Lara Maier, André G Uitterlinden, Andrica C H de Vries, Martine van Grotel, Saskia F M Pluijm, Harald Binder, Benjamin Mayer and 34 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Data in brief, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03297034 (Swiss Childhood Cancer Survivor Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03297034 recruitingnot on this map

Swiss Childhood Cancer Survivor Study (SCCSS)

Typeobservational_patient_registrySponsorUniversity of BernRan2007 to 2050Enrolled4,136ConditionsChildhood Cancer
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 7 countries.

Thorsten LangerDepartment of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.
Eva ClemensPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Linda BroerDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Lara MaierInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University Medical Center, Ulm, Germany.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Andrica C H de VriesPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Martine van GrotelPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Saskia F M PluijmPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Harald BinderGerman Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Benjamin MayerInstitute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Annika von dem KnesebeckDepartment of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.
Julianne ByrneBoyne Research Institute, Drogheda, Ireland.
Eline van Dulmen-den BroederPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Marco CroccoDepartment of Neurooncology, Istituto Giannina Gaslini, Genova, Italy.
Desiree GrabowGerman Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Peter KaatschGerman Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Melanie KaiserGerman Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Claudia SpixGerman Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Line KenborgDanish Cancer Society Research Center, Childhood Cancer Research Group, Copenhagen, Denmark.
Jeanette F WintherDanish Cancer Society Research Center, Childhood Cancer Research Group, Copenhagen, Denmark.
Catherine RechnitzerCopenhagen University Hospital Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Copenhagen, Denmark.
Henrik HasleAarhus University Hospital, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
Tomas KepakUniversity Hospital Brno, Brno, Czech Republic, & International Clinical Research Center (FNUSA-ICRC), Brno, Czech Republic.
Anne-Lotte F van der KooiPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Leontien C KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jarmila KruseovaDepartment of Children Hemato-Oncology, Motol University Hospital Prague, Prague, Czech Republic.
Stefan BielackDepartment of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
Benjamin SorgDepartment of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
Stefanie Hecker-NoltingDepartment of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
Claudia E KuehniInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Marc AnsariDepartment of Pediatrics, Oncology and Hematology Unit, University Hospital of Geneva, Cansearch Research Laboratory, Geneva University, Switzerland.
Martin KompisDepartment of Otolaryngology, Head and Neck Surgery, Inselspital, University of Berne.
Heleen J van der PalPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Ross ParfittDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
Dirk DeusterDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
Peter MatulatDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
Amelie TillmannsDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
Wim J E TissingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Jörn D BeckHospital for Children and Adolescents, University of Erlangen-Nuremberg, Erlangen, Germany.
Susanne ElsnerInstitute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany.
Antoinette Am Zehnhoff-DinnesenDepartment of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
Marry M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Oliver ZolkInstitute of Clinical Pharmacology, Immanuel Klinik Rüdersdorf, Brandenburg Medical School Theodor Fontane, Germany.
PanCareLIFE consortium
Princess Máxima Center · NLJohannes Gutenberg University Mainz · DEUniversity Hospital Münster · DEUniversität Ulm · DEAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NLIstituto Giannina Gaslini · ITOlgahospital · DEAarhus University · DKAarhus University Hospital · DKBoyne Research Institute · IECopenhagen University Hospital · DKDanish Cancer Society · DKFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInternational Clinical Research Center, St. Anne's University Hospital Brno · CZUniversity Hospital in Motol · CZUniversity Hospital of Bern · CHUniversity Medical Center Groningen · NLUniversity of Bern · CHUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (

Indexed as

Adverse drug reactionCancer survivorsChildhood cancerCisplatin: carboplatinDrug-induced ototoxicityGenetic markersMulticenter cohort studyPharmacogenetics

Identifiers

PMID32939381
PMCPMC7477761
OpenAlexW3081227107

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.