ArticleNature2020
Reprogramming roadmap reveals route to human induced trophoblast stem cells.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.
- Microfluidic chips in female reproduction: a systematic review of status, advances, and challenges.Theranostics · 2024Pooled it
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Generation of eight-cell embryo-like cells from human pluripotent stem cells.Nature protocols · 2026Review
- Patient-specific trophoblast stem cells for placental medicine.Trends in molecular medicine · 2026Review
- Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming Innovations.Biomedicines · 2026Review
- Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human.Nature communications · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells.Communications biology · 2026Article
- Epigenetic Deregulation of Transposable Elements Links Developmental Processes and Tumorigenesis.International journal of molecular sciences · 2026Review
- Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells.Cellular and molecular life sciences : CMLS · 2026Review
- Direct Reprogramming of Human Fibroblasts into Fully Functional Trophoblast Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Modeling Aspects of Human Placental Development with Trophoblast Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Review
- Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4.Nature communications · 2025Article
- Stem Cell and Synthetic Embryo Models: Advances, Applications, and Ethical Considerations.Stem cell reviews and reports · 2025Review
- Stem cell models of human embryo implantation and trophoblast invasion.Current opinion in genetics & development · 2025Review
- Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription.Science advances · 2025Article
- Leveraging chorionic villus biopsies for the derivation of patient-specific trophoblast stem cells.Communications biology · 2025Article
- Stepwise strategy for generating human trophoblast stem-like cells from embryonic stem cells reveals specific role of TFAP2C in acquiring self-renewability.Scientific reports · 2025Article
- The building blocks of embryo models: embryonic and extraembryonic stem cells.Cell discovery · 2025Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 9 institutions in 5 countries.
Xiaodong Liu *Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
John F Ouyang *Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1239-1577
Fernando J Rossello *Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-3885-8777
Jia Ping TanDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Kathryn C DavidsonDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Daniela S ValdesDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Jan SchröderDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0001-5270-0605
Yu B Y SunDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-0863-2769
Joseph ChenDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Anja S KnauppDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Guizhi SunDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Hun S ChyAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
Ziyi HuangAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
Jahnvi PfluegerAustralian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Jaber FirasDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Vincent TanoDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Sam BuckberryAustralian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Jacob M PaynterDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Michael R LarcombeDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Daniel PoppeAustralian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0002-6674-8420
Xin Yi ChooDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-1783-0102
Carmel M O'BrienAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.
William A PastorDepartment of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4176-5299
Di ChenDepartment of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Anna L LeichterSingle Cell Innovation Laboratory, University of Melbourne Centre For Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia.
Haroon NaeemMonash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia.
Pratibha TripathiDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Partha P DasDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Alexandra GrubmanDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-4408-4499
David R PowellMonash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia.
Andrew L LaslettAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-4729-8193
Laurent DavidUniversité de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR1064, ITUN, F-44000, Nantes, France.ORCID http://orcid.org/0000-0003-3594-0353
Susan K NilssonAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-7926-7335
Amander T ClarkDepartment of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Ryan ListerAustralian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0001-6637-7239
Christian M NefzgerDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Luciano G MartelottoSingle Cell Innovation Laboratory, University of Melbourne Centre For Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9625-1183
Owen J L RackhamProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore, Singapore. owen.rackham@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-4390-0872
Jose M PoloDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. jose.polo@monash.edu.ORCID http://orcid.org/0000-0002-2531-778X
Australian Regenerative Medicine Institute · AUAustralian Research Council · AUThe University of Melbourne · AUUniversity of California, Los Angeles · USMonash University · AUNational University of Singapore · SGCentre National de la Recherche Scientifique · FRDiscovery Institute · USThe University of Queensland · AU
Funding
Howard Hughes Medical Institute
Abstract
The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embryonic development
Indexed as
Gene Expression RegulationAdultCellular ReprogrammingChromatinEctodermFemaleFibroblastsHumansInduced Pluripotent Stem CellsTranscription, GeneticTrophoblastsChromatin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.