Evidence map›Paper›PMID 32939089›Full record

ArticleNature2020

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.

Mikhail Nikolaev, Olga Mitrofanova, Nicolas Broguiere, Sara Geraldo, Devanjali Dutta, Yoji Tabata, Bilge Elci, Nathalie Brandenberg, Irina Kolotuev, Nikolce Gjorevski and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 369 papers.

0numbers the graph read from it
0cells of the map it votes in
369citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

369 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  6. Review
  7. Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  8. Article
  9. Review
  10. Organoids-on-a-Chip: An Integrating New Technology for Drug Development.International journal of molecular sciences · 2026
    Review
  11. Review
  12. Article
  13. Recent advancements and limitations of intestinal organoids for clinical applications.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  14. Review
  15. Article
  16. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review
  17. Review
  18. Article
  19. Review
  20. Review

309 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mikhail NikolaevLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5955-900X
Olga Mitrofanova *Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-9805-3052
Nicolas Broguiere *Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Sara GeraldoLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Devanjali DuttaLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Yoji TabataLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Bilge ElciLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nathalie BrandenbergLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1609-1862
Irina KolotuevElectron Microscopy Facility, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1433-8048
Nikolce GjorevskiLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Hans CleversOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-3077-5582
Matthias P LutolfLaboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. matthias.lutolf@epfl.ch.ORCID http://orcid.org/0000-0002-5898-305X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology

Indexed as

HomeostasisMorphogenesisTissue ScaffoldsAnimalsBody PatterningCell DifferentiationCell LineageCryptosporidium parvumHuman Embryonic Stem CellsHumansHuman Umbilical Vein Endothelial CellsIntestinesMiceModels, BiologicalOrganoidsRegeneration

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.