Evidence map›Paper›PMID 32939051›Full record

ReviewNature reviews. Nephrology2020

Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project.

Edison Ong, Lucy L Wang, Jennifer Schaub, John F O'Toole, Becky Steck, Avi Z Rosenberg, Frederick Dowd, Jens Hansen, Laura Barisoni, Sanjay Jain and 19 more

Abstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Present and future directions in diabetic kidney disease.Journal of diabetes and its complications · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Edison Ong *Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5159-414X
Lucy L Wang *Allen Institute for Artificial Intelligence, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8752-6635
Jennifer SchaubDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8788-239X
John F O'TooleDepartment of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Becky SteckDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7565-4904
Avi Z RosenbergDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Frederick DowdUW Medicine Research IT, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6199-6345
Jens HansenDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura BarisoniDivision of AI/Computational Pathology, Department of Pathology, and Division of Nephrology, Department of Medicine, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0848-9683
Sanjay JainDivision of Nephrology, School of Medicine, Washington University in St. Louis, St Louis, MO, USA.
Ian H de BoerDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
M Todd ValeriusDivision of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8143-9231
Sushrut S WaikarSection of Nephrology, Boston University Medical Center, Boston, MA, USA.
Christopher ParkKidney Research Institute, University of Washington, Seattle, WA, USA.
Dana C CrawfordDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-6437-6248
Theodore AlexandrovStructural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9464-6125
Christopher R AndertonPacific Northwest National Laboratory, Richland, WA, USA.ORCID http://orcid.org/0000-0002-6170-1033
Christian StoeckertDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5714-991X
Chunhua WengDepartment of Biomedical Informatics, Columbia University, New York, NY, USA.
Alexander D DiehlDepartment of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0000-0001-9990-8331
Christopher J MungallEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Melissa HaendelDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Peter N RobinsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-0736-9199
Jonathan HimmelfarbDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3319-1224
Ravi IyengarDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthias KretzlerDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4064-0582
Sean MooneyDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA. yongqunh@med.umich.edu.
Yongqun HeDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA. sdmooney@uw.edu.ORCID http://orcid.org/0000-0001-9189-9661
Kidney Precision Medicine Project

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI KRETZLER, MATTHIAS · 2017 to 2021
$21.0M
The Monarch Initiative: Linking Diseases to Model Organism ResourcesR24OD011883 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAENDEL, MELISSA A, MUNGALL, CHRISTOPHER J · 2012 to 2024
$16.0M
AKI Matched Phenotype Linked Evaluation with Tissue (AMPLE-Tissue)U01DK114866 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Chirag R Parikh · 2022 to 2026
$2.6M
Cleveland Precision Medicine Chronic Kidney Disease CohortUH3DK114908 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI O'TOOLE, JOHN F., POGGIO, EMILIO DANIEL · 2019 to 2021
$900k
Harvard Chronic Kidney Disease Research Biopsy CenterUH3DK114915 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSAS, SYLVIA E, WAIKAR, SUSHRUT S. · 2019 to 2021
$900k
Harvard Chronic Kidney Disease Research Biopsy CenterUG3DK114915 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSAS, SYLVIA E, WAIKAR, SUSHRUT S. · 2017 to 2018
$713k
NCATS NIH HHS UL1 TR001412NIDDK NIH HHS U01 DK114866NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C 1U2CDK114886NIDDK NIH HHS U2C DK114886NIDDK NIH HHS UG3 DK114915NIDDK NIH HHS UH3 DK114908NIDDK NIH HHS UH3 DK114915NIH HHS R24 OD011883
6 · The paper itself

Abstract

An important need exists to better understand and stratify kidney disease according to its underlying pathophysiology in order to develop more precise and effective therapeutic agents. National collaborative efforts such as the Kidney Precision Medicine Project are working towards this goal through the collection and integration of large, disparate clinical, biological and imaging data from patients with kidney disease. Ontologies are powerful tools that facilitate these efforts by enabling researchers to organize and make sense of different data elements and the relationships between them. Ontologies are critical to support the types of big data analysis necessary for kidney precision medicine, where heterogeneous clinical, imaging and biopsy data from diverse sources must be combined to define a patient's phenotype. The development of two new ontologies - the Kidney Tissue Atlas Ontology and the Ontology of Precision Medicine and Investigation - will support the creation of the Kidney Tissue Atlas, which aims to provide a comprehensive molecular, cellular and anatomical map of the kidney. These ontologies will improve the annotation of kidney-relevant data, and eventually lead to new definitions of kidney disease in support of precision medicine.

Indexed as

Atlases as TopicBiological OntologiesPrecision MedicineBig DataHumansKidney DiseasesPhenotype

Identifiers

PMID32939051
PMCPMC8012202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.