Evidence map›Paper›PMID 32939041›Full record

ArticleEuropean journal of clinical nutrition2021

Secular changes in mid-adulthood body mass index, waist circumference, and low HDL cholesterol between 1990, 2003, and 2018 in Great Britain.

William Johnson, Tom Norris, Mark Hamer

Abstract read
In one paragraph

Article in European journal of clinical nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Cohort Profile Update: The 1970 British Cohort Study (BCS70).International journal of epidemiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William JohnsonSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. W.O.Johnson@lboro.ac.uk.ORCID http://orcid.org/0000-0002-0347-4354
Tom NorrisSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Mark HamerDivision of Surgery and Interventional Sciences, Faculty Medical Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0002-8726-7992

Funding

Medical Research Council MR/P023347/1
6 · The paper itself

Abstract

objectiveTo investigate the extent to which (1) secular changes in mid-adulthood WC are independent of BMI and (2) secular changes in low HDL-C are dependent on WC in each sex.

methodsThe sample comprised 19,406 adults (aged 43-47 years) from three birth cohort studies with BMI and WC measured in 1990, 2003, or 2018; 13,239 participants additionally had HDL-C measured in 2003 or 2018. Quantile regression was used to model differences between 1990-2003 and 2003-2018 in (1) BMI and WC internal Z-scores and (2) WC in cm before and after adjustment for BMI. Binary logistic regression was used to model differences between 2003 and 2018 in low HDL-C, before and after adjustment for BMI or WC.

resultsSecular increases in BMI and WC were larger between 1990 and 2003 than 2003 and 2018 and at the upper ends of the distributions. At the 85th quantile, effect sizes were larger for WC than BMI Z-scores in females but not males. Adjustment for BMI attenuated estimates of secular increases in WC in cm more in males than females. Odds ratios for low HDL-C in 2018 compared to 2003 were 1.73 (95% CI 1.32, 2.28) in males and 1.34 (1.01, 1.78) in females. Adjustment for WC did not substantially change the estimate in males but attenuated the estimate for females to 1.09 (0.81, 1.47).

conclusionsIn women much more so than in men, secular increases in mid-adulthood WC appear to have occurred independently of BMI and largely explain the observed rise in low HDL-C prevalence between 2003 and 2018.

Indexed as

Body Mass IndexAdultCholesterol, HDLFemaleHumansMaleRisk FactorsUnited KingdomWaist CircumferenceCholesterol, HDL

Identifiers

PMID32939041
PMCPMC7610415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.