Evidence map›Paper›PMID 32939028›Full record

ReviewSpinal cord2020

Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system.

M J Mulcahey, Linda A T Jones, Frank Rockhold, Rϋediger Rupp, John L K Kramer, Steven Kirshblum, Andrew Blight, Daniel Lammertse, James D Guest, John D Steeves

Abstract readReview
PubMed Publisher
In one paragraph

Review in Spinal cord, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Exploring the Landscape of Biomarkers in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M J MulcaheyCenter for Outcomes and Measurement, College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, PA, USA. Maryjane.mulcahey@jefferson.edu.ORCID http://orcid.org/0000-0002-0837-714X
Linda A T JonesUniversity of Colorado, Denver, CO, USA.ORCID http://orcid.org/0000-0002-2945-1927
Frank RockholdDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3732-4765
Rϋediger RuppSpinal Cord Center, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3873-1023
John L K KramerInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Steven KirshblumKessler Institute for Rehabilitation, West Orange, NJ, USA.
Andrew BlightAcorda Therapeutics, Inc., Ardsley, NY, USA.
Daniel LammertseCraig Hospital, Englewood, CO, USA.
James D Guest *The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0003-0931-0286
John D Steeves *International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designNarrative review. PURPOSE: To provide an overview of adaptive trial designs, and describe how adaptive methods can address persistent challenges encountered by randomized controlled trials of people with spinal cord injury (SCI).

resultsWith few exceptions, adaptive methodologies have not been incorporated into clinical trial designs of people with SCI. Adaptive methods provide an opportunity to address high study costs, slow recruitment, and excessive amount of time needed to carry out the trial. The availability of existing SCI registries are well poised to support modeling and simulation, both of which are used extensively in adaptive trial designs. Eight initiatives for immediate advancement of adaptive methods in SCI were identified.

conclusionAlthough successfully applied in other fields, adaptive clinical trial designs in SCI clinical trial programs have been narrow in scope and few in number. Immediate application of several adaptive methods offers opportunity to improve efficiency of SCI trials. Concerted effort is needed by all stakeholders to advance adaptive clinical trial design methodology in SCI.

Indexed as

Spinal Cord InjuriesAdaptive Clinical Trials as TopicCentral Nervous SystemHumansRegistriesResearch Design

Identifiers

PMID32939028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.