ArticleScientific reports2020
Age-dependent decline in stress response capacity revealed by proteins dynamics analysis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
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- Cellular oxidants and the proteostasis network: balance between activation and destruction.Trends in biochemical sciences · 2024Review
- The regulatory mechanism of the yeast osmoresponse under different glucose concentrations.iScience · 2023Article
- Relationship between diet quality and depression among Iranian older adults in Tehran.BMC geriatrics · 2022Article
- Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.Biogerontology · 2022Article
- Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities.Probiotics and antimicrobial proteins · 2022Review
- Chromosome-condensed G1 phase yeast cells are tolerant to desiccation stress.Microbial cell (Graz, Austria) · 2022Article
- Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology.Biogerontology · 2021Review
- Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.GeroScience · 2021Article
- Genes implicated inBiology letters · 2021Article
- Understanding the Impact of Industrial Stress Conditions on Replicative Aging inFrontiers in fungal biology · 2021Review
- Replicative Aging in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2020Review
- Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress.Contact (Thousand Oaks (Ventura County, Calif.))Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aging process is regarded as the progressive loss of physiological integrity, leading to impaired biological functions and the increased vulnerability to death. Among various biological functions, stress response capacity enables cells to alter gene expression patterns and survive when facing internal and external stresses. Here, we explored changes in stress response capacity during the replicative aging of Saccharomyces cerevisiae. To this end, we used a high-throughput microfluidic device to deliver intermittent pulses of osmotic stress and tracked the dynamic changes in the production of downstream stress-responsive proteins, in a large number of individual aging cells. Cells showed a gradual decline in stress response capacity of these osmotic-related downstream proteins during the aging process after the first 5 generations. Among the downstream stress-responsive genes and unrelated genes tested, the residual level of response capacity of Trehalose-6-Phosphate Synthase (TPS2) showed the best correlation with the cell remaining lifespan. By monitor dynamics of the upstream transcription factors and mRNA of Tps2, it was suggested that the decline in downstream stress response capacity was caused by the decline of translational rate of these proteins during aging.
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