ArticleNature communications2020
Phase of firing coding of learning variables across the fronto-striatal network during feature-based learning.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Human neuronal firing varies with the frequency of local field potential oscillations.PLoS biology · 2026Article
- Human neuronal firing is modulated by the frequency of local field potential oscillations.bioRxiv : the preprint server for biology · 2025Article
- Unraveling the roles of spatial working memory sustained and selective neurons in prefrontal cortex.Communications biology · 2025Article
- Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum.bioRxiv : the preprint server for biology · 2025Article
- Article
- Spatiotemporal dynamics in large-scale cortical networks.Current opinion in neurobiology · 2022Review
- Anterior cingulate cortex causally supports flexible learning under motivationally challenging and cognitively demanding conditions.PLoS biology · 2022Article
- Brain stimulation competes with ongoing oscillations for control of spike timing in the primate brain.PLoS biology · 2022Article
- When the Whole Is Less Than the Sum of Its Parts: Maximum Object Category Information and Behavioral Prediction in Multiscale Activation Patterns.Frontiers in neuroscience · 2022Article
- Article
- Differentiating Melancholic and Non-melancholic Major Depressive Disorder Using Fractional Amplitude of Low-Frequency Fluctuations.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The prefrontal cortex and striatum form a recurrent network whose spiking activity encodes multiple types of learning-relevant information. This spike-encoded information is evident in average firing rates, but finer temporal coding might allow multiplexing and enhanced readout across the connected network. We tested this hypothesis in the fronto-striatal network of nonhuman primates during reversal learning of feature values. We found that populations of neurons encoding choice outcomes, outcome prediction errors, and outcome history in their firing rates also carry significant information in their phase-of-firing at a 10-25 Hz band-limited beta frequency at which they synchronize across lateral prefrontal cortex, anterior cingulate cortex and anterior striatum when outcomes were processed. The phase-of-firing code exceeds information that can be obtained from firing rates alone and is evident for inter-areal connections between anterior cingulate cortex, lateral prefrontal cortex and anterior striatum. For the majority of connections, the phase-of-firing information gain is maximal at phases of the beta cycle that were offset from the preferred spiking phase of neurons. Taken together, these findings document enhanced information of three important learning variables at specific phases of firing in the beta cycle at an inter-areally shared beta oscillation frequency during goal-directed behavior.
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