ArticleNature communications2020
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 97 citations in OpenAlex.
- Evolution, Mechanisms, and Therapeutic Implications of Mobile Tetracycline Destructases.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Emergence of tet(X6) and blaBMC microbiology · 2026Article
- Molecular epidemiology and emergingAntimicrobial agents and chemotherapy · 2026Article
- Identification and characteristics of a novel acquired aminoglycoside phosphotransferase, APH(3')-IVb, fromAntimicrobial agents and chemotherapy · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Threat and Control ofFoods (Basel, Switzerland) · 2025Review
- Interorder horizontal gene transfer ofAntimicrobial agents and chemotherapy · 2025Article
- A Novel Metallo-β-Lactamase AMM-1 From Alteromonas mangrovi Reveals a Cryptic Environmental Reservoir of Carbapenem Resistance.Microbial biotechnology · 2025Article
- Genetic insights intoMicrobial genomics · 2025Article
- Emergence of a novel high-level tigecycline resistance geneAntimicrobial agents and chemotherapy · 2025Article
- Temporal and spatial co-occurrence of pacific oyster mortality and increased planktoniciScience · 2025Article
- Emergence of tigecycline-resistantFrontiers in microbiology · 2025Article
- ESKAPE in China: epidemiology and characteristics of antibiotic resistance.Emerging microbes & infections · 2024Review
- Concurrence of Inactivation Enzyme-Encoding GenesFoods (Basel, Switzerland) · 2024Article
- Comparative resistomics analysis of multidrug-resistant Chryseobacteria.Environmental microbiology reports · 2024Article
- Whole-genome sequence and resistance determinants of four Elizabethkingia anophelis clinical isolates collected in Hanoi, Vietnam.Scientific reports · 2024Article
- Genome-based assessment of antimicrobial resistance reveals the lineage specificity of resistance and resistance gene profiles inMicrobiology spectrum · 2024Article
- Distribution and spread of tigecycline resistance geneFrontiers in cellular and infection microbiology · 2024Article
- Identification of novel Tet(X6)-Tet(X2) recombinant variant inFrontiers in microbiology · 2024Article
- Sensitive and rapid detection of tet(X2) ~ tet(X5) by loop-mediated isothermal amplification based on visual OTG dye.BMC microbiology · 2023Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emergence of tigecycline-resistance tet(X) gene orthologues rendered tigecycline ineffective as last-resort antibiotic. To understand the potential origin and transmission mechanisms of these genes, we survey the prevalence of tet(X) and its orthologues in 2997 clinical E. coli and K. pneumoniae isolates collected nationwide in China with results showing very low prevalence on these two types of strains, 0.32% and 0%, respectively. Further surveillance of tet(X) orthologues in 3692 different clinical Gram-negative bacterial strains collected during 1994-2019 in hospitals in Zhejiang province, China reveals 106 (2.7%) tet(X)-bearing strains with Flavobacteriaceae being the dominant (97/376, 25.8%) bacteria. In addition, tet(X)s are found to be predominantly located on the chromosomes of Flavobacteriaceae and share similar GC-content as Flavobacteriaceae. It also further evolves into different orthologues and transmits among different species. Data from this work suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance gene tet(X).
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