Evidence map›Paper›PMID 32938724›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer.

Kayla J Steinberger, Mary A Forget, Andrey A Bobko, Nicole E Mihalik, Marieta Gencheva, Julie M Roda, Sara L Cole, Xiaokui Mo, E Hannah Hoblitzell, Randall Evans and 5 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Monocyte programming by cancer therapy.Frontiers in immunology · 2022
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Kayla J SteinbergerIn Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV 26506.ORCID 0000-0002-2882-8593
Mary A ForgetDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.
Andrey A BobkoRobert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506.ORCID 0000-0003-1576-5236
Nicole E MihalikRobert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506.ORCID 0000-0002-8220-6613
Marieta GenchevaIn Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV 26506.
Julie M RodaDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-5631-9908
Sara L ColeDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-4422-3172
Xiaokui MoDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.
E Hannah HoblitzellIn Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV 26506.
Randall EvansDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.
Amy C GrossDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.
Leni MoldovanDivision of Pulmonary Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-1967-2408
Clay B MarshRobert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506.
Valery V KhramstovIn Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV 26506.
Timothy D EubankIn Vivo Multifunctional Magnetic Resonance Center, West Virginia University, Morgantown, WV 26506; tdeubank@hsc.wvu.edu.
West Virginia University · USLung Institute · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1M
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2001 to 2010
$22.8M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4M
West Virginia Flow Cytometry Core FacilityP30GM103488 · NIGMS · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2012 to 2016
$4.8M
In vivo monitoring of tumor microenvironment regulation for macrophagesR01CA194013 · NCI · WEST VIRGINIA UNIVERSITY · PI Timothy D Eubank, Valery V Khramtsov · 2015 to 2026
$3.5M
Profiling chemical tumor microenvironment: Application for diagnostics & therapyR01CA192064 · NCI · WEST VIRGINIA UNIVERSITY · PI EUBANK, TIMOTHY D, KHRAMTSOV, VALERY V · 2015 to 2024
$3.4M
NF-kappaB:an Akt target &regulator of monocyte survivalR01HL067176 · NHLBI · OHIO STATE UNIVERSITY · PI MARSH, CLAY B · 2001 to 2011
$3.2M
Cell and Molecular Biology Training Program at West Virginia UniversityT32GM133369 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Zoica Cerasela Dinu, MICHAEL D SCHALLER · 2019 to 2026
$2.0M
The role of epigenetics and miRNAs in IPFR01HL109481 · NHLBI · WEST VIRGINIA UNIVERSITY · PI MARSH, CLAY B, PIPER, MELISSA G · 2012 to 2015
$1.6M
Prediction and Mechanism of Carbon Nanotube-Induced FibrosisR01HL095579 · NHLBI · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2010 to 2013
$1.5M
COBRE FOR SIGNAL TRANSDUCTION AND CANCER PHASE IIIP30RR032138 · NCRR · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2011 to 2011
$1.1M
NCI NIH HHS R00 CA131552NCI NIH HHS R01 CA192064NCI NIH HHS R01 CA194013NCRR NIH HHS P20 RR016440NCRR NIH HHS P30 RR032138NHLBI NIH HHS R01 HL067176NHLBI NIH HHS R01 HL095579NHLBI NIH HHS R01 HL109481NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P30 GM103488NIGMS NIH HHS T32 GM133369NIGMS NIH HHS U54 GM104942NIMH NIH HHS R01 MH067167
6 · The paper itself

Abstract

Tie2-expressing monocytes/macrophages (TEMs) are a distinct subset of proangiogenic monocytes selectively recruited to tumors in breast cancer. Because of the hypoxic nature of solid tumors, we investigated if oxygen, via hypoxia-inducible transcription factors HIF-1α and HIF-2α, regulates TEM function in the hypoxic tumor microenvironment. We orthotopically implanted PyMT breast tumor cells into the mammary fat pads of syngeneic LysMcre, HIF-1α

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell Line, TumorEndothelial PAS Domain-Containing Protein 1FemaleHypoxia-Inducible Factor 1, alpha SubunitMacrophagesMammary Neoplasms, ExperimentalMiceNeoplasm ProteinsOxygenReceptor, TIE-2Basic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Hif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNeoplasm ProteinsOxygenReceptor, TIE-2Tek protein, mouse

Identifiers

PMID32938724
PMCPMC7596922
OpenAlexW4232921145

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.