ArticleScience advances2020
Medial forebrain bundle structure is linked to human impulsivity.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Midbrain-Hippocampus Structural Connectivity Selectively Predicts Motivated Memory Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Trial
- Mesocorticolimbic Dopamine-Reward Tract Alterations and the 'Dark Side' of Methamphetamine Addiction.Addiction biology · 2026Article
- A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls.bioRxiv : the preprint server for biology · 2024Article
- Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.Brain : a journal of neurology · 2024Article
- Effect of positive social comparative feedback on the resting state connectivity of dopaminergic neural pathways: A preliminary investigation.Neurobiology of learning and memory · 2024Article
- AnbioRxiv : the preprint server for biology · 2024Article
- Blunted Neurobehavioral Loss Anticipation Predicts Relapse to Stimulant Drug Use.Biological psychiatry · 2024Article
- Child maltreatment among deaf and hard-of-hearing adolescent students: associations with depression and anxiety.Frontiers in psychology · 2024Article
- Structural projections to the nucleus accumbens link to impulsive components of human risk preference.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- An fMRI-Based Brain Marker of Individual Differences in Delay Discounting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Brain tract structure predicts relapse to stimulant drug use.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases asBrain sciences · 2022Article
- Temporal dynamics of affect in the brain: Evidence from human imaging and animal models.Neuroscience and biobehavioral reviews · 2022Review
- Magnetic resonance imaging of the dopamine system in schizophrenia - A scoping review.Frontiers in psychiatry · 2022Article
- Diverging prefrontal cortex fiber connection routes to the subthalamic nucleus and the mesencephalic ventral tegmentum investigated with long range (normative) and short range (ex-vivo high resolution) 7T DTI.Brain structure & function · 2022Article
- Nucleus accumbens projections: Validity and reliability of fiber reconstructions based on high-resolution diffusion-weighted MRI.Human brain mapping · 2021Article
- The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder.Translational psychiatry · 2021Article
- White-matter tract connecting anterior insula to nucleus accumbens predicts greater future motivation in adolescents.Developmental cognitive neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative research indicates that projections from midbrain dopamine nuclei [including the ventral tegmental area (VTA)] to the ventral striatum [including the nucleus accumbens (NAcc)] critically support motivated behavior. Using diffusion-weighted imaging and probabilistic tractography in humans, we characterized the trajectory and structure of two tracts connecting the VTA and NAcc, as well as others connecting the substantia nigra and dorsal striatum. Decreased structural coherence of an inferior VTA-NAcc tract was primarily and replicably associated with increased trait impulsivity and also distinguished individuals with a stimulant use disorder from healthy controls. These findings suggest that decreased coherence of the inferior VTA-NAcc tract is associated with increased impulsivity in humans and identify a previously uncharacterized structural target for diagnosing disorders marked by impulsivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.