ArticleJournal of the American Society of Nephrology : JASN2020
Larger Nephron Size and Nephrosclerosis Predict Progressive CKD and Mortality after Radical Nephrectomy for Tumor and Independent of Kidney Function.
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Finerenone in People with CKD, Type 2 Diabetes, and History of Nephrectomy.Clinical journal of the American Society of Nephrology : CJASN · 2026Trial
- Multimodal deep learning model for AI-based functional prognostic risk stratification in patients undergoing radical nephrectomy.Nature communications · 2026Article
- Multifactorial chronic kidney disease and the kidney capacity-workload balance.Nature reviews. Nephrology · 2026Review
- Lower Podocyte Number per Glomerulus Associates With Progressive CKD.Kidney international reports · 2025Article
- Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model.Kidney international reports · 2025Article
- Stenosis of the glomerulotubular neck in progressive chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Exploring the subtle and novel renal pathological changes in diabetic nephropathy using clustering analysis with deep learning.Scientific reports · 2025Article
- Glomerular and Nephron Size and Kidney Disease Outcomes: A Comparison of Manual Versus Deep Learning Methods in Kidney Pathology.Kidney medicine · 2025Article
- Consequences of low estimated glomerular filtration rate either before or early after kidney donation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Characterization of arteriosclerosis based on computer-aided measurements of intra-arterial thickness.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.Kidney international · 2024Article
- Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Observational
- Glomerular Hypertrophy and Initial Dip in Estimated Glomerular Filtration Rate Following Dapagliflozin Administration.Kidney international reports · 2024Article
- Capillary rarefaction: a missing link in renal and cardiovascular disease?Angiogenesis · 2024Review
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- Effect of Dataset Size and Medical Image Modality on Convolutional Neural Network Model Performance for Automated Segmentation: A CT and MR Renal Tumor Imaging Study.Journal of digital imaging · 2023Article
- Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure.Journal of the American Society of Nephrology : JASN · 2023Article
- AI in the Loop: functionalizing fold performance disagreement to monitor automated medical image segmentation workflows.Frontiers in radiology · 2023Article
- Glomerular hyperfiltration and hypertrophy: an evaluation of maximum values in pathological indicators to discriminate "diseased" from "normal".Frontiers in medicine · 2023Review
- Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNephron hypertrophy and nephrosclerosis may be important determinants of CKD and mortality. However, studies of outcomes associated with these microstructural features have been limited to small tissue specimens from patients selected for either good kidney health or known kidney disease.
methodsTo determine whether microstructural features are predictive of progressive CKD and mortality outcomes, we studied patients who underwent a radical nephrectomy for a tumor. Large wedge sections of renal parenchyma distal to the tumor were stained and scanned into high-resolution images; we annotated the cortex and all glomeruli to calculate glomerular volume, cortex volume per glomerulus, and percentage of globally sclerotic glomeruli. Morphometric measurements also included percentages of artery luminal stenosis and interstitial fibrosis/tubular atrophy (IF/TA) of the cortex. At follow-up visits every 6-12 months, we determined which patients experienced progressive CKD (defined as dialysis, kidney transplantation, or a 40% decline from postnephrectomy eGFR). Cox models for these outcomes were adjusted for age, sex, body mass index, hypertension, diabetes, smoking, eGFR, and proteinuria.
resultsAmong 936 patients (mean age, 64 years; postnephrectomy baseline eGFR, 48 ml/min per 1.73 m
conclusionsAfter a radical nephrectomy, larger nephrons and nephrosclerosis predicted progressive CKD, and IF/TA predicted noncancer mortality. Morphometric analysis of renal parenchyma can predict noncancer clinical events in patients long after their radical nephrectomy.
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