ArticleCancer research2020
Cancers from Novel
Open access · greenAbstract readComment
In one paragraph
Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Genetics, genomics and clinical features of adenomatous polyposis.Familial cancer · 2025Review
- Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes.Cancer research · 2025Article
- PolED: a manually curated database of functional studies of POLE and POLD1 variants reported in humans.Database : the journal of biological databases and curation · 2025Article
- Altered dNTP pools accelerate tumor formation in mice.Nucleic acids research · 2024Article
- Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides.Nature genetics · 2024Article
- Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome.NPJ precision oncology · 2024Article
- DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.Cell reports · 2024Article
- Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1.Genome medicine · 2023Article
- Distinct and opposite effects of leukemogenicProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels.Nucleic acids research · 2022Article
- Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development.NAR cancer · 2022Article
- Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.Nucleic acids research · 2021Article
- Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.Cancer research · 2020Article
- DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer.Cancers · 2020Review
Corrections and comments
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Authors and funding
36 authors at 12 institutions in 5 countries.
Melissa A Galati *Program in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Karl P Hodel *Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana.
Miki S GamsProgram in Developmental and Stem Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sumedha SudhamanProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Taylor BridgeThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Walter J ZahurancikThe Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio.
Nathan A UngerleiderTulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana.
Vivian S ParkDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana.
Ayse B ErcanProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-3612-3515
Lazar JoksimovicProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Iram SiddiquiDepartment of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Robert SiddawayThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Melissa EdwardsProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Richard de BorjaProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8181-6348
Dana ElshaerProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Jiil ChungProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Victoria J ForsterProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nuno M NunesProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-3879-9757
Melyssa AronsonThe Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre for Digestive Disease, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID 0000-0002-7503-5799
Xia WangH Lee Moffitt Cancer Centre and Research Institute, Tampa, Florida.ORCID 0000-0001-6650-5229
Jagadeesh RamdasDepartment of Pediatrics, Geisinger Medical Center, Danville, Pennsylvania.
Andrea SeeleyDepartment of Pediatrics, Geisinger Medical Center, Danville, Pennsylvania.ORCID 0000-0002-2213-0012
Tomasz SarosiekNZOZ Magodent, Warsaw, Poland.
Gavin P DunnDepartment of Neurological Surgery, Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri.
Jonathan N ByrdDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri.
Oz MordechaiDepartment of Pediatric Hematology Oncology, Rambam Health Care Campus, Haifa, Israel.ORCID 0000-0002-4340-9290
Carol DurnoDivision of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada.
Alberto MartinDepartment of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Adam ShlienProgram in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Eric BouffetDivision of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6832-6539
Zucai SuoThe Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio.
James G JacksonDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana.
Cynthia E HawkinsThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Cynthia J GuidosProgram in Developmental and Stem Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
Zachary F Pursell *Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana.
Uri Tabori *Program in Genetics and Genome Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. uri.tabori@sickkids.ca.
Hospital for Sick Children · CAUniversity of Toronto · CATulane University · USGeisinger Medical Center · USFlorida State University · USHope Center for Neurological Disorders · USMoffitt Cancer Center · USMount Sinai Hospital · CANZOZ Centrum Alergologii · PLRambam Health Care Campus · ILThe Ohio State University · USWashington University in St. Louis · US
Funding
Investigation of human DNA polymerase epsilon variantsR01ES028271 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI Zachary F Pursell · 2017 to 2026
$3.6MMutagenesis, tumorigenesis and human DNA polymerase epsilonR56ES026821 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI PURSELL, ZACHARY F · 2016 to 2016
$150kCIHR PJT-156006NIEHS NIH HHS R01 ES028271NIEHS NIH HHS R56 ES026821
Abstract
PubMed holds no abstract for this paper.
Indexed as
DNA Polymerase IINeoplasmsAnimalsHumansImmune Checkpoint InhibitorsMiceMutationPoly-ADP-Ribose Binding ProteinsDNA Polymerase IIImmune Checkpoint InhibitorsPoly-ADP-Ribose Binding Proteins
Identifiers
What OpenQuestion holds
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Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.