ArticleAnnals of the rheumatic diseases2020
Risk of venous thromboembolism in knee, hip and hand osteoarthritis: a general population-based cohort study.
Article in Annals of the rheumatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A systematic review and meta-analysis of the association between the D-dimer and rheumatic diseases.Immunity, inflammation and disease · 2024Pooled it
- Effects of blood flow restriction combined with electrical stimulation on muscle functions and performance in university football players with knee osteoarthritis.Scientific reports · 2025Trial
- The effect of dual-task training in older adults with total hip arthroplasty: a randomized controlled trial.BMC musculoskeletal disorders · 2025Trial
- Association of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Inflammatory mechanisms underlying metabolic syndrome-associated and potential treatments.Osteoarthritis and cartilage open · 2025Article
- Osteoarthritis and the risk of sleep apnea: a general population-based cohort study.Clinical rheumatology · 2025Article
- Article
- Management of Venous Thromboembolism After Hip and Knee Arthroplasty.Journal of orthopaedics and sports medicine · 2025Article
- Article
- Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013-2014 and 2017-2018).Frontiers in public health · 2025Article
- Obesity aggravates the role of C-reactive protein on knee pain: A cross-sectional analysis with NHANES data.Immunity, inflammation and disease · 2024Article
- A Bibliometric study of the top 100 most-cited papers in high tibial osteotomy.Annals of medicine and surgery (2012) · 2024Review
- Osteoarthritis and hypertension: observational and Mendelian randomization analyses.Arthritis research & therapy · 2024Observational
- The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.Drug design, development and therapy · 2024Article
- Anterior cruciate ligament tear increases the risk of venous thromboembolism: a population-based cohort study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Effects of psychological distress on the general health to self-reported pain and function outcome relationship in knee arthroplasty: A causal mediation study.Osteoarthritis and cartilage open · 2022Article
- Postoperative venous thromboembolism event increases risk of readmissions and reoperation following total joint arthroplasty: a propensity-matched cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Body surface area affected by psoriasis and the risk for psoriatic arthritis: a prospective population-based cohort study.Rheumatology (Oxford, England) · 2022Article
- Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis.Annals of the rheumatic diseases · 2022Article
- Predicting Venous Thrombosis in Osteoarthritis Using a Machine Learning Algorithm: A Population-Based Cohort Study.Journal of personalized medicine · 2022Article
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOsteoarthritis is a leading cause of immobility and joint replacement, two strong risk factors for venous thromboembolism (VTE). We aimed to examine the relation of knee, hip and hand osteoarthritis to the risk of VTE and investigate joint replacement as a potential mediator.
methodsWe conducted three cohort studies using data from The Health Improvement Network. Up to five individuals without osteoarthritis were matched to each case of incident knee (n=20 696), hip (n=10 411) or hand (n=6329) osteoarthritis by age, sex, entry time and body mass index. We examined the relation of osteoarthritis to VTE (pulmonary embolism and deep vein thrombosis) using a multivariable Cox proportional hazard model.
resultsVTE developed in 327 individuals with knee osteoarthritis and 951 individuals without osteoarthritis (2.7 vs 2.0 per 1000 person-years), with multivariable-adjusted HR being 1.38 (95% CI 1.23 to 1.56). The indirect effect (HR) of knee osteoarthritis on VTE through knee replacement was 1.07 (95% CI 1.01 to 1.15), explaining 24.8% of its total effect on VTE. Risk of VTE was higher in hip osteoarthritis than non-osteoarthritis (3.3 vs 1.8 per 1000 person-years; multivariable-adjusted HR=1.83, 95% CI 1.56 to 2.13). The indirect effect through hip replacement yielded an HR of 1.14 (95% CI 1.04 to 1.25), explaining 28.1% of the total effect. No statistically significant difference in VTE risk was observed between hand osteoarthritis and non-osteoarthritis (1.5 vs 1.6 per 1000 person-years; multivariable-adjusted HR=0.88, 95% CI 0.67 to 1.16).
conclusionOur large population-based cohort study provides the first evidence that knee or hip osteoarthritis, but not hand osteoarthritis, was associated with an increased risk of VTE, and such an association was partially mediated through knee or hip replacement.
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