Evidence map›Paper›PMID 32938507›Full record

ReviewDevelopment and psychopathology2020

Affording autism an early brain development re-definition.

Ami Klin, Megan Micheletti, Cheryl Klaiman, Sarah Shultz, John N Constantino, Warren Jones

Open access · greenAbstract readReview
In one paragraph

Review in Development and psychopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Who, when, where, and why: A systematic review of "late diagnosis" in autism.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Social communication development in a contingent world: insights from autism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  6. Article
  7. Article
  8. Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. The earlier the better: An RCT of treatment timing effects for toddlers on the autism spectrum.Autism : the international journal of research and practice · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Ami KlinMarcus Autism Center, Atlanta, GA, USA.
Megan MichelettiDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Cheryl KlaimanMarcus Autism Center, Atlanta, GA, USA.
Sarah ShultzMarcus Autism Center, Atlanta, GA, USA.
John N ConstantinoDepartments of Psychiatry and Pediatrics, Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine, St Louis, MO, USA.
Warren JonesMarcus Autism Center, Atlanta, GA, USA.
Center for Autism and Related Disorders · USChildren's Healthcare of Atlanta · USEmory University · USMarcus (United States) · USThe University of Texas at Austin · USWashington University in St. Louis · US

Funding

The ontogeny of social vocal engagement and its derailment in autismP50MH100029 · NIMH · EMORY UNIVERSITY · PI RAMSAY, GORDON JAMES · 2012 to 2021
$20.1M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
Community-viable screening for ASD in 9-month-old infants using quantitative eye-tracking assays of social visual engagementR01MH121363 · NIMH · EMORY UNIVERSITY · PI JONES, WARREN · 2019 to 2024
$3.8M
Measuring gene-environment transactions to identify sensitive periods for infant social behavior & brain growthR01MH118285 · NIMH · EMORY UNIVERSITY · PI JONES, WARREN, SHULTZ, SARAH · 2019 to 2024
$3.7M
Pathogenic insight into ASD from the study of neonatal brain-behavior transitionsK01MH108741 · NIMH · EMORY UNIVERSITY · PI SHULTZ, SARAH · 2016 to 2020
$857k
FAMILY ENVIRONMENT AND DEPRESSION IN ADOLESCENTSF31MH011925 · NIMH · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI SAEZ-SANTIAGO, EMILY · 1998 to 2000
$20k
NICHD NIH HHS P50 HD103525NIMH NIH HHS F31 MH011925NIMH NIH HHS K01 MH108741NIMH NIH HHS P50 MH100029NIMH NIH HHS R01 MH118285NIMH NIH HHS R01 MH121363
6 · The paper itself

Abstract

The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD in early brain development terms, with a view to revisit the world of opportunities afforded by current science to optimize children's outcomes despite the risks that they are born with. This view is presented here to counter outdated notions that potentially devastating disability is determined the moment a child is born, and that these burdens are inevitable, with opportunities for improvement being constrained to only alleviation of symptoms or limited improvements in adaptive skills. The impetus for this piece is the concern that such views of complex neurodevelopmental conditions, such as ASD, can become self-fulfilling science and policy, in ways that are diametrically opposed to what we currently know, and are learning every day, of how genetic risk becomes, or not, instantiated as lifetime disabilities.

Indexed as

Autism Spectrum DisorderAutistic DisorderBrainChildHumansautism spectrum disorderbrain developmentdefinitionearly diagnosisearly intervention

Identifiers

PMID32938507
PMCPMC7880583
OpenAlexW3087507630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.