Evidence map›Paper›PMID 32938484›Full record

ArticleCardiovascular ultrasound2020

Quantification of left ventricular mass by echocardiography compared to cardiac magnet resonance imaging in hemodialysis patients.

Sören Jendrik Grebe, Uwe Malzahn, Julian Donhauser, Dan Liu, Christoph Wanner, Vera Krane, Fabian Hammer

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cardiovascular ultrasound, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01691053 (Phase II Trial to Evaluate the Efficacy and Safety of Spironolactone in Hemodialysis Patients), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01691053 phase2completednot on this map

Phase II Trial to Evaluate the Efficacy and Safety of Spironolactone in Hemodialysis Patients

TypeinterventionalSponsorWuerzburg University HospitalRan2012 to 2018Enrolled118ConditionsEnd Stage Renal Disease / HemodialysisArmsSpironolactone, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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  7. Left ventricular remodeling and long-term outcomes of aortic stenosis patients receiving 19 mm Mosaic.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sören Jendrik GrebeDepartment of Medicine I, University Hospital of Würzburg, Würzburg, Germany. soeren.grebe@uk-erlangen.de.ORCID http://orcid.org/0000-0001-6415-6424
Uwe MalzahnClinical Trial Center Würzburg, University Hospital Würzburg, Würzburg, Germany.
Julian DonhauserDepartment of Diagnostic and Interventional Radiology, University Hospital of Würzburg, Würzburg, Germany.
Dan LiuDivision of Cardiology, University of Würzburg, Würzburg, Germany.
Christoph WannerDepartment of Medicine I, University Hospital of Würzburg, Würzburg, Germany.
Vera KraneDepartment of Medicine I, University Hospital of Würzburg, Würzburg, Germany.
Fabian HammerDepartment of Internal Medicine B, Division of Cardiology, University Medicine, Greifswald, Germany.
University of Würzburg · DEUniversitätsklinikum Würzburg · DEUniversitätsklinikum Erlangen · DEUniversitätsmedizin Greifswald · DE

Funding

Bundesministerium für Bildung und Forschung 01KG1202
6 · The paper itself

Abstract

backgroundLeft ventricular hypertrophy (LVH), defined by the left ventricular mass index (LVMI), is highly prevalent in hemodialysis patients and a strong independent predictor of cardiovascular events. Compared to cardiac magnetic resonance imaging (CMR), echocardiography tends to overestimate the LVMI. Here, we evaluate the diagnostic performance of transthoracic echocardiography (TTE) compared to CMR regarding the assessment of LVMI in hemodialysis patients.

methodsTTR and CMR data for 95 hemodialysis patients who participated in the MiREnDa trial were analyzed. The LVMI was calculated by two-dimensional (2D) TTE-guided M-mode measurements employing the American Society of Echocardiography (ASE) and Teichholz (Th) formulas, which were compared to the reference method, CMR.

resultsLVH was present in 44% of patients based on LVMI measured by CMR. LVMI measured by echocardiography correlated moderately with CMR, ASE: r = 0.44 (0.34-0.62); Th: r = 0.44 (0.32-0.62). Compared to CMR, both echocardiographic formulas overestimated LVMI (mean ∆LVMI (ASE-CMR): 19.5 ± 19.48 g/m

conclusionsThe ASE and Th formulas overestimate LVMI in hemodialysis patients. However, the overestimation is less with the Th formula, particularly with increasing LVMI. The results suggest that the Th formula should be preferred for measurement of LVMI in chronic hemodialysis patients.

trial registrationThe data was derived from the following clinical trial: NCT01691053 , registered on 19 September 2012 before enrollment of the first participant.

Indexed as

Renal DialysisAgedEchocardiographyFemaleHumansHypertrophy, Left VentricularMagnetic Resonance Imaging, CineMaleMiddle AgedASE formulaEchocardiographyHemodialysisLeft ventricular hypertrophyLeft ventricular mass indexTeichholz formula

Identifiers

PMID32938484
PMCPMC7495823
OpenAlexW3087762791

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.