Evidence map›Paper›PMID 32938458›Full record

ArticleBMC biology2020

Altered brain-wide auditory networks in a zebrafish model of fragile X syndrome.

Lena Constantin, Rebecca E Poulsen, Leandro A Scholz, Itia A Favre-Bulle, Michael A Taylor, Biao Sun, Geoffrey J Goodhill, Gilles C Vanwalleghem, Ethan K Scott

Open access · goldAbstract read
In one paragraph

Article in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Article
  10. Article
  11. Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Whole-brain imaging of freely-moving zebrafish.Frontiers in neuroscience · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lena ConstantinQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Rebecca E PoulsenQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Leandro A ScholzQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Itia A Favre-BulleQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Michael A TaylorAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
Biao SunQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Geoffrey J GoodhillQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Gilles C VanwalleghemQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia. g.vanwalleghem@uq.edu.au.
Ethan K ScottQueensland Brain Institute, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia. ethan.scott@uq.edu.au.ORCID 0000-0003-3150-9216
The University of Queensland · AU

Funding

An integrated platform for studying sensory networks in the vertebrate brainRF1NS118406 · NINDS · UNIVERSITY OF QUEENSLAND · PI SCOTT, ETHAN KIME · 2020 to 2020
$1.2M
Australian Research Council DP110103612Australian Research Council DP140102036National Health and Medical Research Council APP1066887NINDS NIH HHS RF1 NS118406Simons Foundation 399432Simons Foundation 625793
6 · The paper itself

Abstract

backgroundLoss or disrupted expression of the FMR1 gene causes fragile X syndrome (FXS), the most common monogenetic form of autism in humans. Although disruptions in sensory processing are core traits of FXS and autism, the neural underpinnings of these phenotypes are poorly understood. Using calcium imaging to record from the entire brain at cellular resolution, we investigated neuronal responses to visual and auditory stimuli in larval zebrafish, using fmr1 mutants to model FXS. The purpose of this study was to model the alterations of sensory networks, brain-wide and at cellular resolution, that underlie the sensory aspects of FXS and autism.

resultsCombining functional analyses with the neurons' anatomical positions, we found that fmr1

conclusionsWe demonstrated that fmr1

Indexed as

ZebrafishAnimalsAutistic DisorderBrainDisease Models, AnimalFragile X SyndromeAuditory perceptionAutism spectrum disorderBrain/physiopathologyCalcium imagingCGaMPFragile X syndromeGraph theoryLight-sheet microscopySensory systemsZebrafish

Identifiers

PMID32938458
PMCPMC7493858
OpenAlexW3087648251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.