Evidence map›Paper›PMID 32938440›Full record

ArticleBMC veterinary research2020

IgE reactivity to fish allergens from Pacific cod (Gadus macrocephalus) in atopic dogs.

Ichiro Imanishi, Jumpei Uchiyama, Keijiro Mizukami, Junichi Kamiie, Keigo Kurata, Keita Iyori, Masato Fujimura, Kuniyoshi Shimakura, Koji Nishifuji, Masahiro Sakaguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ichiro ImanishiLaboratory of Veterinary Microbiology I, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
Jumpei UchiyamaLaboratory of Veterinary Microbiology I, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
Keijiro MizukamiLaboratory of Veterinary Microbiology I, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
Junichi KamiieLaboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Keigo KurataInstitute of Tokyo Environmental Allergy, ITEA Inc, Bunkyo-ku, Tokyo, Japan.
Keita IyoriVet Derm Tokyo, Laboratory and Clinical Dermatology Services, Kouto-ku, Tokyo, Japan.
Masato FujimuraFujimura Animal Hospital, Minoo, Osaka, Japan.
Kuniyoshi ShimakuraDepartment of Food Science and Technology, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, Japan.
Koji NishifujiLaboratory of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Masahiro SakaguchiLaboratory of Veterinary Microbiology I, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan. sakagum@azabu-u.ac.jp.ORCID http://orcid.org/0000-0002-7594-1943
Azabu University · JPFujita Animal Hospital · JPTokyo University of Agriculture and Technology · JPTokyo University of Marine Science and Technology · JP

Funding

Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 15K07756MEXT supported program for the Private University Research Branding Project, 2016-2020
6 · The paper itself

Abstract

backgroundIgE reactivity to fish allergens in atopic dogs, which are used as models for food allergy, has not been elucidated to date. We investigated IgE reactivity to crude extracts and purified allergens derived from the Pacific cod (Gadus macrocephalus) in atopic dogs to identify the allergenic proteins of cod.

resultsThe levels of specific IgE to crude cod extracts were measured in the sera of 179 atopic dogs, including 27 dogs with cod allergy, using enzyme-linked immunosorbent assay (ELISA). Specific IgE to crude cod extracts were present in 36 (20%) of the 179 atopic dogs and in 12 (44%) of the 27 dogs with cod allergy. The allergens in crude cod extracts were analyzed by ELISA, immunoblotting, and liquid chromatography-tandem mass spectrometry. In allergen component analysis, IgE reactivity to tropomyosin and enolase was observed in the sera of dogs with cod allergy. IgE reactivity to parvalbumin, collagen, and tropomyosin was evaluated using the sera of atopic dogs that tested positive for specific IgE to crude cod extracts. Among the 36 dogs with IgE reactivity to crude cod extracts, 9 (25%), 14 (39%), and 18 (50%) dogs tested positive for specific IgE to parvalbumin, collagen, and tropomyosin, respectively.

conclusionsThe IgE reactivity to cod allergens observed in dogs was similar to that in humans, and this finding further supports the use of atopic dogs with fish allergy as a model for fish allergy in humans.

Indexed as

AnimalsCollagenDermatitis, AtopicDog DiseasesDogsFemaleFish ProteinsFood HypersensitivityGadiformesImmunoglobulin EMaleModels, AnimalParvalbuminsTropomyosinCollagenFish ProteinsImmunoglobulin EParvalbuminsTropomyosinAllergen componentAnimal modelAtopic dermatitisFish allergyImmunoglobulin E

Identifiers

PMID32938440
PMCPMC7493343
OpenAlexW3087639656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.