Evidence map›Paper›PMID 32938410›Full record

ArticleBMC psychiatry2020

Cognitive remediation following electroconvulsive therapy in patients with treatment resistant depression: randomized controlled trail of an intervention for relapse prevention - study protocol.

Nele Van de Velde, Mitchel Kappen, Ernst H W Koster, Kristof Hoorelbeke, Hannelore Tandt, Pieter Verslype, Chris Baeken, Rudi De Raedt, Gilbert Lemmens, Marie-Anne Vanderhasselt

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04383509 (Cognitive Remediation Following Electroconvulsive Therapy in Patients With Treatment Resistant Depression), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04383509 naterminatednot on this map

Cognitive Remediation Following Electroconvulsive Therapy in Patients With Treatment Resistant Depression: Randomized Controlled Trail of an Intervention for Relapse Prevention

TypeinterventionalSponsorUniversity GhentRan2020 to 2023Enrolled21ConditionsDepressive Episode, Electroconvulsive Therapy, Cognitive RemediationArmsCognitive Control Training, Active Control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Nele Van de VeldeDepartment of Psychiatry, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium. Nele.vandevelde2@uzgent.be.ORCID 0000-0002-7781-8607
Mitchel KappenDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Ernst H W KosterDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Kristof HoorelbekeDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Hannelore TandtDepartment of Psychiatry, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Pieter VerslypeDepartment of Anesthesiology, Ghent University Hospital, Ghent, Belgium.
Chris BaekenDepartment of Psychiatry, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Rudi De RaedtDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Gilbert LemmensDepartment of Psychiatry, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Marie-Anne VanderhasseltDepartment of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Ghent University Hospital · BE

Funding

King Baudouin Foundation Belgium KBS 2018-J1130650-209563Universitair Ziekenhuis Gent BOF16/GOA/017Universiteit Gent BOFSTA2017002501
6 · The paper itself

Abstract

backgroundMajor depressive episode (MDE) is worldwide one of the most prevalent and disabling mental health conditions. In cases of persistent non-response to treatment, electroconvulsive therapy (ECT) is a safe and effective treatment strategy with high response rates. Unfortunately, longitudinal data show low sustained response rates with 6-month relapse rates as high as 50% using existing relapse prevention strategies. Cognitive side effects of ECT, even though transient, might trigger mechanisms that increase relapse in patients who initially responded to ECT. Among these side effects, reduced cognitive control is an important neurobiological driven vulnerability factor for depression. As such, cognitive control training (CCT) holds promise as a non-pharmacological strategy to improve long-term effects of ECT (i.e., increase remission, and reduce depression relapse). METHOD/

designEighty-eight patients aged between 18 and 70 years with MDE who start CCT will be included in this randomized controlled trial (RCT). Following (partial) response to ECT treatment (at least a 25% reduction of clinical symptoms), patients will be randomly assigned to a computer based CCT or active placebo control. A first aim of this RCT is to assess the effects of CCT compared to an active placebo condition on depression symptomatology, cognitive complaints, and quality of life. Secondly, we will monitor patients every 2 weeks for a period of 6 months following CCT/active placebo, allowing the detection of potential relapse of depression. Thirdly, we will assess patient evaluation of the addition of cognitive remediation to ECT using qualitative interview methods (satisfaction, acceptability and appropriateness). Finally, in order to further advance our understanding of the mechanisms underlying effects of CCT, exploratory analyses will be conducted using video footage collected during the CCT/active control phase of the study. DISCUSSION: Cognitive remediation will be performed following response to ECT, and an extensive follow-up period will be employed. Positive findings would not only benefit patients by decreasing relapse, but also by increasing acceptability of ECT, reducing the burden of cognitive side-effects.

trial registrationThe study is registered with ClinicalTrials.gov . Study ID: NCT04383509 Trial registration date: 12.05.2020.

Indexed as

Cognitive RemediationDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyMajor Depressive DisorderAdolescentAdultAgedHumansMiddle AgedRandomized Controlled Trials as TopicSecondary PreventionTreatment OutcomeYoung AdultCognitive remediationElectroconvulsive therapyMajor depression

Identifiers

PMID32938410
PMCPMC7493867
OpenAlexW3087027294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.