Evidence map›Paper›PMID 32938402›Full record

ArticleBMC bioinformatics2020

miRTissue

Antonino Fiannaca, Laura La Paglia, Massimo La Rosa, Riccardo Rizzo, Alfonso Urso

Open access · goldAbstract read
In one paragraph

Article in BMC bioinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonino FiannacaCNR-ICAR, National Research Council of Italy, via Ugo La Malfa 153, Palermo, 90146, Italy.
Laura La PagliaCNR-ICAR, National Research Council of Italy, via Ugo La Malfa 153, Palermo, 90146, Italy.
Massimo La RosaCNR-ICAR, National Research Council of Italy, via Ugo La Malfa 153, Palermo, 90146, Italy. massimo.larosa@icar.cnr.it.ORCID http://orcid.org/0000-0001-6718-7269
Riccardo RizzoCNR-ICAR, National Research Council of Italy, via Ugo La Malfa 153, Palermo, 90146, Italy.
Alfonso UrsoCNR-ICAR, National Research Council of Italy, via Ugo La Malfa 153, Palermo, 90146, Italy.
National Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-coding RNAs include different classes of molecules with regulatory functions. The most studied are microRNAs (miRNAs) that act directly inhibiting mRNA expression or protein translation through the interaction with a miRNAs-response element. Other RNA molecules participate in the complex network of gene regulation. They behave as competitive endogenous RNA (ceRNA), acting as natural miRNA sponges to inhibit miRNA functions and modulate the expression of RNA messenger (mRNA). It became evident that understanding the ceRNA-miRNA-mRNA crosstalk would increase the functional information across the transcriptome, contributing to identify new potential biomarkers for translational medicine.

resultsWe present miRTissue

conclusionsThe study of ceRNA networks and its dynamics in cancer tissue could be applied in many fields of translational biology, as the investigation of new cancer biomarker, both diagnostic and prognostic, and also in the investigation of new therapeutic strategies of intervention. In this scenario, miRTissue

Indexed as

Gene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMicroRNAsPrognosisRNA, NeoplasmMicroRNAsRNA, NeoplasmceRNA interactionmiRNA spongemiRNA-target interactionTCGATumour

Identifiers

PMID32938402
PMCPMC7493844
OpenAlexW3085347643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.