Evidence map›Paper›PMID 32938236›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.

Joanna Sikora, Maria Podsiedlik, Tadeusz Pietras, Marcin Kosmalski, Mikołaj Matłoka, Rafał Moszczyński-Petkowski, Maciej Wieczorek, Magdalena Markowicz-Piasecka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joanna SikoraLaboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Maria PodsiedlikDepartment of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Tadeusz PietrasDepartment of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Marcin KosmalskiDepartment of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Mikołaj MatłokaResearch and Development Department, Celon Pharma S.A, Łomianki, Poland.
Rafał Moszczyński-PetkowskiResearch and Development Department, Celon Pharma S.A, Łomianki, Poland.
Maciej WieczorekResearch and Development Department, Celon Pharma S.A, Łomianki, Poland.
Magdalena Markowicz-PiaseckaLaboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PLCelon Pharma (Poland) · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The symptoms of Alzheimer's disease (AD) do not include only memory loss and cognitive decline but also neuropsychiatric manifestation. These AD-related symptoms are usually treated with the aid of antipsychotics; however, their effects on cognition and safety remain unexplored. The present study determines the effects of quetiapine, an atypical antipsychotic, and two imidazo[1,2-a]pyrimidine-based inhibitors of PDE10A on the activity of human cholinesterases. Quetiapine moderately inhibited BuChE (IC

Indexed as

AcetylcholinesteraseAntipsychotic AgentsButyrylcholinesteraseCholinesterase InhibitorsDonepezilDose-Response Relationship, DrugHealthy VolunteersHumansMolecular StructurePhosphodiesterase InhibitorsPhosphoric Diester HydrolasesQuetiapine FumarateStructure-Activity RelationshipAcetylcholinesteraseAntipsychotic AgentsButyrylcholinesteraseCholinesterase InhibitorsDonepezilPDE10A protein, humanPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesQuetiapine Fumarateacetylcholinesterase inhibitorsAlzheimer’s diseasedonepezilPDE10A inhibitorsquetiapine

Identifiers

PMID32938236
PMCPMC7534323
OpenAlexW3087067738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.