ArticleTropical medicine and infectious disease2020
Clinical, Virological, and Immunological Findings in Patients with Toscana Neuroinvasive Disease in Croatia: Report of Three Cases.
Article in Tropical medicine and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Dogs as sentinel hosts for sand-fly-borne infections in the Mediterranean Basin: a multinational serological survey.Parasites & vectors · 2026Article
- Clinical review of Toscana virus: a Mediterranean Neuroinvasive Phlebovirus.Frontiers in epidemiology · 2026Review
- Imported aseptic meningitis due to Toscana virus infection in Austria since 2006, including a case series from 2023.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
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- Toscana virus - an emerging Mediterranean arbovirus transmitted by sand flies.The Journal of general virology · 2024Review
- Glucosylceramide in bunyavirus particles is essential for virus binding to host cells.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Urine: A Pitfall for Molecular Detection of Toscana Virus? An Analytical Proof-of-Concept Study.Viruses · 2024Article
- Article
- Current Status of Vector-Borne Diseases in Croatia: Challenges and Future Prospects.Life (Basel, Switzerland) · 2023Review
- Quantification of Antiviral Cytokines in Serum, Cerebrospinal Fluid and Urine of Patients with Tick-Borne Encephalitis in Croatia.Vaccines · 2022Article
- Detection of Tahyna Orthobunyavirus-Neutralizing Antibodies in Patients with Neuroinvasive Disease in Croatia.Microorganisms · 2022Article
- Zoonotic and reverse zoonotic transmission of viruses between humans and pigs.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Review
- Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection.Viruses · 2021Article
- Emerging and Neglected Viruses of Zoonotic Importance in Croatia.Pathogens (Basel, Switzerland) · 2021Review
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur. We report three cases of neuroinvasive TOSV infection detected in Croatia. Two patients aged 21 and 54 years presented with meningitis, while a 22-year old patient presented with meningoencephalitis and right-sided brachial plexitis. Cerebrospinal fluid (CSF), serum, and urine samples were collected and tested for neuroinvasive arboviruses: tick-borne encephalitis, West Nile, Usutu, TOSV, Tahyna, and Bhanja virus. In addition, CSF and serum samples were tested for the anti-viral cytokine response. High titers of TOSV IgM (1000-3200) and IgG (3200-10,000) antibodies in serum samples confirmed TOSV infection. Antibodies to other phleboviruses (sandfly fever Sicilian/Naples/Cyprus virus) were negative. CSF samples showed high concentrations of interleukin 6 (IL-6; range 162.32-2683.90 pg/mL), interferon gamma (IFN-γ; range 110.12-1568.07 pg/mL), and IL-10 (range 28.08-858.91 pg/mL), while significantly lower cytokine production was observed in serum. Two patients recovered fully. The patient with a brachial plexitis improved significantly at discharge. The presented cases highlight the need of increasing awareness of a TOSV as a possible cause of aseptic meningitis/meningoencephalitis during summer months. Association of TOSV and brachial plexitis with long-term sequelae detected in one patient indicates the possibility of more severe disease, even in young patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.