Evidence map›Paper›PMID 32937843›Full record

ArticleFoods (Basel, Switzerland)2020

Biological Properties of a Citral-Enriched Fraction of

Marzia Pucci, Stefania Raimondo, Chiara Zichittella, Vincenza Tinnirello, Valeria Corleone, Gioacchino Aiello, Marta Moschetti, Alice Conigliaro, Simona Fontana, Riccardo Alessandro

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  8. Effect of a Change in the CaClFoods (Basel, Switzerland) · 2023
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marzia PucciDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Stefania RaimondoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-5413-1303
Chiara ZichittellaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Vincenza TinnirelloAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, Italy.
Valeria CorleoneAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, Italy.
Gioacchino AielloAgrumaria Corleone s.p.a., Via S. Corleone, 12-Zona Ind. Brancaccio, 90124 Palermo, Italy.
Marta MoschettiDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-5302-9649
Alice ConigliaroDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Simona FontanaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0003-4681-2170
Riccardo AlessandroDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-9935-1040
University of Palermo · IT

Funding

"Salute in tazza: innovative soluzioni per l'isolamento e l'applicazione industriale, anche in capsule, di composti biofunzionali ottenuti da agrumi di Sicilia" PON I&C - MISE F/050039/01-03/X32.
6 · The paper itself

Abstract

Lemon essential oil (LEO) is a well-known flavoring agent with versatile biological activities. In the present study, we have isolated and characterized four citral-enriched fractions of winter LEO. We reported that in murine and human macrophages the pre-treatment with a mix of these fractions (Cfr-LEO) reduces the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 induced by LPS. In addition, Cfr-LEO counteracts LPS-induced oxidative stress, as shown by the increase in the GSH/GSSG ratio in comparison to cells treated with LPS alone. Overall, the results reported here encourage the application of EO fractions, enriched in citral, in the nutraceutical industry, not only for its organoleptic properties but also for its protective action against inflammation and oxidative stress.

Indexed as

citralCitrus limon (L.) Osbeckessential oilinflammationnutraceuticalsoxidative stress

Identifiers

PMID32937843
PMCPMC7555671
OpenAlexW3086893324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.